Effect of Apoptosis Induction of Ailanthus altissima on Human Lung Carcinoma Cells
- Title
- Effect of Apoptosis Induction of Ailanthus altissima on Human Lung Carcinoma Cells
- Author
- 엄애선
- Keywords
- Ailanthus altissima; Lung cancer; Apoptosis; Bax; Bcl-2
- Issue Date
- 2011-10
- Publisher
- 경상대학교 농업생명과학연구원(구 경상대학교 농업자원이용연구소)
- Citation
- 농업생명과학연구. Vol. 45 No. 5 (2011) pp. 91~96
- Abstract
- We investigated the inhibitory effects of solvent extracts from Ailanthus altissima in A549 human lung cancer cell. A. altissima has been recognized as a traditional healthy food due to its various biological activities against hypertension, strokes, fever, pain, neuralgia, inflammation, and cancer effects. Recently, it has been reported that the extracts of various wild vegetables show strong anti-cancer properties by induction of apoptosis. However, the mechanisms of their cytotoxicity in human lung cancer cells have been poorly understood. The present study was investigated the effects of solvent extracts from A. altissima on cell growth and apoptosis on A549 human lung cancer cells. A treatment of A. altissima inhibited the growth of A549 cells in a dose-dependent manner by inducing apoptosis. Especially, the chloroform fraction showed the highest anti-cancer effect among five kinds of fractions. And also, induction of apoptosis by chloroform fraction were associated with down-regulation of Bcl-2, and up-regulation of pro-apoptotic Bax expression. From these results, A. altissima may have a therapeutic potential in human lung cancer cells and as a functional food.
- URI
- http://ials.gnu.ac.kr/gnuboard4/data/paper/20120713-03145012.%C8%B2%C0%AF%C1%F8_p.91-96.pdfhttps://repository.hanyang.ac.kr/handle/20.500.11754/70500
- ISSN
- 1598-5504
- Appears in Collections:
- COLLEGE OF HUMAN ECOLOGY[S](생활과학대학) > FOOD & NUTRITION(식품영양학과) > Articles
- Files in This Item:
- ials.gnu.ac.kr.pdfDownload
- Export
- RIS (EndNote)
- XLS (Excel)
- XML