Histamine and TNF-a release by rat peritoneal mast cells
- Title
- Histamine and TNF-a release by rat peritoneal mast cells
- Author
- 류재숙
- Keywords
- Trichomonas vaginalis; rat; mast cell; migration; histamine; TNF-alpha; TUMOR-NECROSIS-FACTOR; IMMUNE-RESPONSE; IN-VIVO; INFECTION; ASSOCIATION; MIGRATION; HEPARIN; MOUSE; MICE
- Issue Date
- 2011-03
- Publisher
- EDP SCIENCES S A, 17, AVE DU HOGGAR, PA COURTABOEUF, BP 112, F-91944 LES ULIS CEDEX A, FRANCE
- Citation
- PARASITE -PARIS- ,Vol.18 No.1 [2011],49-56
- Abstract
- Mast cells have been reported to be predominant in the vaginal smears of patients infected with T. vaginalis. In this study, we investigated whether T. vaginalis could induce mast cells to migrate and to produce TNF-alpha and histamine. Rat peritoneal mast cells (RPMC), a primary mast cell, were used for the study. T. vaginalis induced an increase in chemotactic migration of the mast cells toward excretory and secretory product (ESP) of T. vaginalis, and the mast cells activated with T. vaginalis showed an increased release of histamine and TNF-alpha. Therefore, mast cells may be involved in the inflammatory response caused by T. vaginalis.
- URI
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3671398https://repository.hanyang.ac.kr/handle/20.500.11754/69582
- ISSN
- 1252-607X
- Appears in Collections:
- COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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