Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | 박용순 | - |
dc.contributor.author | 홍성은 | - |
dc.date.accessioned | 2018-04-18T06:07:10Z | - |
dc.date.available | 2018-04-18T06:07:10Z | - |
dc.date.issued | 2018-02 | - |
dc.identifier.uri | https://repository.hanyang.ac.kr/handle/20.500.11754/68221 | - |
dc.identifier.uri | http://hanyang.dcollection.net/common/orgView/200000432683 | en_US |
dc.description.abstract | The objective of this study was to develop multi-layer nanoemulsions (NEs) using a layer-by-layer technique to improve the cellular uptake and intragastric stability of α-Tocopherol (α-TC). α-TC-loaded multi-layer NEs were prepared using lecithin (PRI-NE) followed by coating with chitosan as the second layer (SEC-NE) and dextran sulfate as the third layer (TER-NE) using a high-energy-method. Multi-layer NEs were ranged from 96 to 160 nm and exhibited a high entrapment efficiency of 80-91%. Cellular association, antioxidant activity, and in vitro bioaccessibility of α-TC-loaded multi-layer NEs were significantly better than those of non-nanoencapsulated α-TC (p<0.05). The cellular association of TER-NE was the highest, 1.3-2-fold higher than that of non-nanoencapsulated α-TC. Also, the cellular antioxidant ability was PRI-NE (40%), SEC-NE (45%), and TER-NE (50%). The amount of free fatty acids released after digestion was decreased after multi-layer nano-encapsulation. Moreover, bioaccessibility of TER-NE was two-fold higher than that of non-nanoencapsulated α-TC. These results indicated that the cellular association, antioxidant activity, gastrointestinal stability, and in vitro bioaccessibility of α-TC could be enhanced by multi-layer nano-encapsulation. Furthermore, TER-NE was the most effective multi-layer NE structure to improve cellular association and intragastric stability. | - |
dc.publisher | 한양대학교 | - |
dc.title | 알파토코페롤의 세포투과율 증진을 위한 다중나노에멀젼의 제조 및 특성 | - |
dc.title.alternative | Preparation and characterization of multi-layer nanoemulsion containing α-tocopherol for enhancing cellular uptake | - |
dc.type | Theses | - |
dc.contributor.googleauthor | 홍성은 | - |
dc.contributor.alternativeauthor | Hong, Seong Eun | - |
dc.sector.campus | S | - |
dc.sector.daehak | 대학원 | - |
dc.sector.department | 식품영양학과 | - |
dc.description.degree | Master | - |
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