Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이종민 | - |
dc.date.accessioned | 2018-04-16T02:38:28Z | - |
dc.date.available | 2018-04-16T02:38:28Z | - |
dc.date.issued | 2012-01 | - |
dc.identifier.citation | Neurobiology of Aging, Vol.33, No.1 [2012], p200.e23 ~ 200.e31 | en_US |
dc.identifier.issn | 0197-4580 | - |
dc.identifier.uri | http://www.sciencedirect.com/science/article/pii/S0197458010003180 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/67567 | - |
dc.description.abstract | The Rhesus monkey is a useful model for examining age-related as well as other neurological and developmental effects on the brain, because of the extensive neuroanatomical homology to the human brain, the reduced occurrence of neurological diseases such as Alzheimer's disease, and the possibility of obtaining relevant behavioral data and post-mortem tissue for histological analyses. In this study, cortical thickness measurements based on a cortical surface modeling technique were applied for the first time to investigate cortical thickness patterns in the rhesus monkey brain, and were used to evaluate regional age related effects across a wide range of ages. Age related effects were observed in several cortical areas, in particular in the somato-sensory and motor cortices, where a robust negative correlation of cortical thickness with age was observed, similar to that found in humans. In contrast, results for monkeys compared with humans show significant interspecies differences in cortical thickness patterns in the frontal and the inferior temporal regions. | en_US |
dc.description.sponsorship | This work was supported by NIH grants P01-AG000001, R21-AG02878 and P51-RR000165. For international collaboration, author Jong-Min Lee has received support from the Korea Science and Engineering Foundation (KOSEF) NRL program grant funded by the Korea government (MEST) [grant number R0A-2007-000-20068-0]. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsevier Science B.V., Amsterdam. | en_US |
dc.subject | Aging brain | en_US |
dc.subject | Rhesus monkey | en_US |
dc.subject | Gray matter | en_US |
dc.subject | Cerebral cortex | en_US |
dc.subject | Cortical surface modeling | en_US |
dc.subject | Cortical thickness | en_US |
dc.title | Age-related effects on cortical thickness patterns of the Rhesus monkey brain | en_US |
dc.type | Article | en_US |
dc.relation.no | 1 | - |
dc.relation.volume | 33 | - |
dc.identifier.doi | 10.1016/j.neurobiolaging.2010.07.010 | - |
dc.relation.page | 200.e23-200.e31 | - |
dc.relation.journal | NEUROBIOLOGY OF AGING | - |
dc.contributor.googleauthor | Koo, B. B. | - |
dc.contributor.googleauthor | Schettler, S. P. | - |
dc.contributor.googleauthor | Murray, D. E. | - |
dc.contributor.googleauthor | Lee, J. M. | - |
dc.contributor.googleauthor | Killiany, R. J. | - |
dc.contributor.googleauthor | Rosene, D. L. | - |
dc.contributor.googleauthor | Kim, D. S. | - |
dc.contributor.googleauthor | Ronen, I. | - |
dc.relation.code | 2012206990 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF ENGINEERING[S] | - |
dc.sector.department | DIVISION OF ELECTRICAL AND BIOMEDICAL ENGINEERING | - |
dc.identifier.pid | ljm | - |
dc.identifier.researcherID | 55852397100 | - |
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