Synthesis of Radioiodinated Carbocyclic Cytosine Analogues
- Title
- Synthesis of Radioiodinated Carbocyclic Cytosine Analogues
- Author
- 이학준
- Keywords
- Carbocyclic nucleoside; Radioiodine; PET; Radiopharmaceutical; Labeling
- Issue Date
- 2011-06
- Publisher
- Korean Chemical Society
- Citation
- Bulletin of the Korean Chemical Society, v.32, no.6.2011년, pp.1931 - 1935
- Abstract
- The synthesis of carbocyclic analogues of normal nucleosides has grown exclusively since they have shown potential antiviral and antitumor activities. Radiolabeled cis-1-[4-(hydroxy-methyl)-cyclopent-2-enyl]-5-$[^{124}I]$-iodocytosine (carbocyclic d4IC) and cis-1-[4-(hydroxy-methyl)-cyclopent-2-enyl]-5-(2-$[^{124}I]$iodovinyl)cytosine(carbocyclic d4IVC) were synthesized. The synthetic route employed Pd(0)-catalyzed coupling reaction together with organotin and exchange reaction for radioiodination as key reactions. Carbocyclic $[^{124}I]$d4IC gave more than 75% radiochemical yield with greater than 95% radiochemical purity. Carbocyclic $[^{124}I]$d4IVC gave more than 80% radiochemical yield with greater than 95% radiochemical purity.
- URI
- http://koreascience.or.kr/article/ArticleFullRecord.jsp?cn=JCGMCS_2011_v32n6_1931
- ISSN
- 0253-2964
- DOI
- 10.5012/bkcs.2011.32.6.1931
- Appears in Collections:
- GRADUATE SCHOOL[S](대학원) > BIONANOTECHNOLOGY(바이오나노학과) > Articles
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