Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이학준 | - |
dc.date.accessioned | 2018-04-15T05:26:44Z | - |
dc.date.available | 2018-04-15T05:26:44Z | - |
dc.date.issued | 2011-06 | - |
dc.identifier.citation | Bulletin of the Korean Chemical Society, v.32, no.6.2011년, pp.1931 - 1935 | en_US |
dc.identifier.issn | 0253-2964 | - |
dc.identifier.uri | http://koreascience.or.kr/article/ArticleFullRecord.jsp?cn=JCGMCS_2011_v32n6_1931 | - |
dc.description.abstract | The synthesis of carbocyclic analogues of normal nucleosides has grown exclusively since they have shown potential antiviral and antitumor activities. Radiolabeled cis-1-[4-(hydroxy-methyl)-cyclopent-2-enyl]-5-$[^{124}I]$-iodocytosine (carbocyclic d4IC) and cis-1-[4-(hydroxy-methyl)-cyclopent-2-enyl]-5-(2-$[^{124}I]$iodovinyl)cytosine(carbocyclic d4IVC) were synthesized. The synthetic route employed Pd(0)-catalyzed coupling reaction together with organotin and exchange reaction for radioiodination as key reactions. Carbocyclic $[^{124}I]$d4IC gave more than 75% radiochemical yield with greater than 95% radiochemical purity. Carbocyclic $[^{124}I]$d4IVC gave more than 80% radiochemical yield with greater than 95% radiochemical purity. | en_US |
dc.description.sponsorship | the Korean Ministry of Education through the second stage of the BK21 project for the Hanyang University graduate program and Seoul Metropolitan Government for Seoul Science Fellowship for financial support. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Korean Chemical Society | en_US |
dc.subject | Carbocyclic nucleoside | en_US |
dc.subject | Radioiodine | en_US |
dc.subject | PET | en_US |
dc.subject | Radiopharmaceutical | en_US |
dc.subject | Labeling | en_US |
dc.title | Synthesis of Radioiodinated Carbocyclic Cytosine Analogues | en_US |
dc.type | Article | en_US |
dc.relation.no | 6 | - |
dc.relation.volume | 32 | - |
dc.identifier.doi | 10.5012/bkcs.2011.32.6.1931 | - |
dc.relation.page | 1931-1935 | - |
dc.relation.journal | BULLETIN OF THE KOREAN CHEMICAL SOCIETY | - |
dc.contributor.googleauthor | Rhee, Hak-June | - |
dc.contributor.googleauthor | Ahn, Hyun-Seok | - |
dc.contributor.googleauthor | An, Gwang-Il | - |
dc.relation.code | 2011214307 | - |
dc.sector.campus | S | - |
dc.sector.daehak | GRADUATE SCHOOL[S] | - |
dc.sector.department | DEPARTMENT OF BIONANOTECHNOLOGY | - |
dc.identifier.pid | hrhee | - |
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