Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 신인철 | - |
dc.date.accessioned | 2018-04-14T07:45:24Z | - |
dc.date.available | 2018-04-14T07:45:24Z | - |
dc.date.issued | 2012-07 | - |
dc.identifier.citation | Journal of Biological Chemistry, 2012, 287(31), P.25954~26017 | en_US |
dc.identifier.issn | 0021-9258 | - |
dc.identifier.uri | http://www.jbc.org/content/287/31/25954.full | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/66113 | - |
dc.description.abstract | The biochemical mechanism by which the human tumorous imaginal disc1(S) (hTid-1(S)) interferes with actin cytoskeleton organization in keratinocytes of human skin epidermis was investigated. We found that hTid-1, specifically hTid-1(S), interacts with MK5, a p38-regulated/activated protein kinase, and inhibits the protein kinase activity of MK5 that phosphorylates heat shock protein HSP27 in cultured HeLa cells. Thus, hTid-1(S) expression inhibits the phosphorylation of HSP27 known to play important roles in F-actin polymerization and actin cytoskeleton organization. The interplay between MK5/HSP27 signaling and hTid-1(S) expression was supported by the inhibition of HSP27 phosphorylation and MK5 activity in HeLa cells in response to hypoxia during which hTid-1(S) expression was down-regulated. We also found that overexpression of hTid-1(S) results in the inhibition of HSP27 phosphorylation, F-actin polymerization, and actin cytoskeleton organization in transduced HaCaT keratinocytes. This study further proposes that the loss of hTid-1(S) expression in the basal layer of skin epidermis correlates with the enhanced HSP27 phosphorylation, keratinocyte hyperproliferation, and excess actin cytoskeleton organization in lesional psoriatic skin. | en_US |
dc.language.iso | en | en_US |
dc.publisher | AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC | en_US |
dc.subject | Cell Migration | en_US |
dc.subject | Cytoskeleton | en_US |
dc.subject | Keratinocytes | en_US |
dc.subject | p38 MAPK | en_US |
dc.subject | Psoriasis | en_US |
dc.subject | F-actin | en_US |
dc.subject | HSP27 | en_US |
dc.subject | MK5 | en_US |
dc.subject | Epidermis | en_US |
dc.subject | hTid-1 | en_US |
dc.title | Absence of a Human DnaJ Protein hTid-1(S) Correlates with Aberrant Actin Cytoskeleton Organization in Lesional Psoriatic Skin | en_US |
dc.type | Article | en_US |
dc.relation.no | 31 | - |
dc.relation.volume | 287 | - |
dc.identifier.doi | 10.1074/jbc.M111.313809 | - |
dc.relation.page | 25954-25963 | - |
dc.relation.journal | JOURNAL OF BIOLOGICAL CHEMISTRY | - |
dc.contributor.googleauthor | Ji Hye, Choi | - |
dc.contributor.googleauthor | Dae-Kyoung, Choi | - |
dc.contributor.googleauthor | Kyung-Cheol, Sohn | - |
dc.contributor.googleauthor | Sang Su, Kwak | - |
dc.contributor.googleauthor | Jinkyu, Suk | - |
dc.contributor.googleauthor | Jong-Soon, Lim | - |
dc.contributor.googleauthor | Incheol, Shin | - |
dc.contributor.googleauthor | Sung-Woo, Kim | - |
dc.contributor.googleauthor | Jeung-Hoon, Lee | - |
dc.contributor.googleauthor | Cheol O, Joe | - |
dc.relation.code | 2012204730 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF NATURAL SCIENCES[S] | - |
dc.sector.department | DEPARTMENT OF LIFE SCIENCE | - |
dc.identifier.pid | incheol | - |
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