Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 심지원 | - |
dc.date.accessioned | 2018-04-03T07:50:24Z | - |
dc.date.available | 2018-04-03T07:50:24Z | - |
dc.date.issued | 2014-09 | - |
dc.identifier.citation | ELIFE, 2014, 3(), P. 1-18 | en_US |
dc.identifier.issn | 2050-084X | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4185420/ | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/57355 | - |
dc.description.abstract | Blood progenitors within the lymph gland, a larval organ that supports hematopoiesis in Drosophila melanogaster, are maintained by integrating signals emanating from niche-like cells and those from differentiating blood cells. We term the signal from differentiating cells the "equilibrium signal" in order to distinguish it from the "niche signal". Earlier we showed that Equilibrium signaling utilizes Pvr (the Drosophila PDGF/VEGF receptor), STAT92E, and Adenosine deaminase-related growth factor A (ADGF-A) [1]. Little is known about how this signal initiates during hematopoietic development. To identify new genes involved in lymph gland blood progenitor maintenance, particularly those involved in equilibrium signaling, we performed a genetic screen that identified bip1 (bric brac interacting protein 1) and Nucleoporin (Nup98) as additional regulators of the equilibrium signal. We show that the products of these genes along with the Bip1-interacting protein RpS8 (Ribosomal protein S8) are required for the proper expression of Pvr. | en_US |
dc.description.sponsorship | We thank Amir Yavari, Julia Manasson, Tanya Hioe, Sean Mofidi, Jesse Zaretsky, and Tina Muhkerjee for assistance generating the HHLT-gal4 line and with various aspects of the screen. We thank JohnMerriam (UCLA) for use of the LA lines and John and Lisa Fessler (UCLA) for the kind gift of anti-Pxn antibodies. Lastly, we thank Ira Clark, John Merriam, and members of the Banerjee Lab for discussionof the project and comments on the manuscript. | en_US |
dc.language.iso | en | en_US |
dc.publisher | ELIFE SCIENCES PUBLICATIONS LTD, SHERATON HOUSE, CASTLE PARK, CAMBRIDGE, CB3 0AX, ENGLAND | en_US |
dc.subject | EMBRYONIC STEM-CELLS | en_US |
dc.subject | NUCLEAR-PORE | en_US |
dc.subject | HEMATOPOIETIC PROGENITORS | en_US |
dc.subject | GENE-REGULATION | en_US |
dc.subject | BTB/POZ DOMAIN | en_US |
dc.subject | ACUTE-LEUKEMIA | en_US |
dc.subject | LYMPH GLAND | en_US |
dc.subject | NUP98 GENE | en_US |
dc.subject | PROTEIN | en_US |
dc.subject | IDENTIFICATION | en_US |
dc.title | Pvr expression regulators in equilibrium signal control and maintenance of Drosophila blood progenitors | en_US |
dc.type | Article | en_US |
dc.relation.volume | 3 | - |
dc.identifier.doi | 10.7554/eLife.03626 | - |
dc.relation.page | 3626-3626 | - |
dc.relation.journal | ELIFE | - |
dc.contributor.googleauthor | Mondal, Bama Charan | - |
dc.contributor.googleauthor | Shim, Jiwon | - |
dc.contributor.googleauthor | Evans, Cory J. | - |
dc.contributor.googleauthor | Banerjee, Utpal | - |
dc.relation.code | 2014028793 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF NATURAL SCIENCES[S] | - |
dc.sector.department | DEPARTMENT OF LIFE SCIENCE | - |
dc.identifier.pid | jshim | - |
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