Adiposity, Adipokines, and Exhaled Nitric Oxide in Healthy Adults Without Asthma
- Title
- Adiposity, Adipokines, and Exhaled Nitric Oxide in Healthy Adults Without Asthma
- Author
- 윤호주
- Keywords
- adipokines; adipose-derived hormones; adiposity; airway inflammation; body mass index; exhaled nitric oxide
- Issue Date
- 2011-12
- Publisher
- Informa Healthcare
- Citation
- The Journal of asthma, Feb 2011, 48(2), P.177-182
- Abstract
- Background. Epidemiological studies have shown that obesity/adiposity is closely associated with asthma in terms of development, severity, and control of asthma. However, effects of obesity/adiposity on airway inflammation are not well known in subjects without asthma. We assessed whether fractional exhaled nitric oxide (FeNO), a marker of eosinophilic airway inflammation, was associated with obesity/adiposity in nonasthmatic healthy adults. Methods. We measured FeNO and serum levels of adipose-derived hormones and adipokines in 117 adult subjects without a previous diagnosis of asthma or current asthmatic symptoms. Associations between FeNO and measures of obesity/adiposity [body mass index (BMI), body fat mass, and body fat percentages] were examined by correlation analyses and uni- and multivariate linear regression analyses. Results. FeNO was not significantly associated with BMI, body fat mass, or body fat percentage by a multivariate linear regression model, adjusting for age, gender, chronic rhinitis, atopy, and lung function. No significant association of FeNO with serum levels of leptin, adiponectin, tumor necrosis factor (TNF)-α, or interleukin (IL)-6 was observed. Conclusions. These findings suggest that in healthy subjects without asthma, obesity/adiposity has no significant effect on eosinophilic airway inflammation and that hormones and systemic inflammation derived from adipose tissue do not affect eosinophilic airway inflammation.
- URI
- http://www.tandfonline.com/doi/abs/10.3109/02770903.2010.529223?journalCode=ijas20http://hdl.handle.net/20.500.11754/55112
- ISSN
- 0277-0903; 1532-4303
- DOI
- 10.3109/02770903.2010.529223
- Appears in Collections:
- COLLEGE OF MEDICINE[S](의과대학) > ETC
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