Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 윤호주 | - |
dc.date.accessioned | 2018-04-02T08:53:17Z | - |
dc.date.available | 2018-04-02T08:53:17Z | - |
dc.date.issued | 2011-12 | - |
dc.identifier.citation | The Journal of asthma, Feb 2011, 48(2), P.177-182 | en_US |
dc.identifier.issn | 0277-0903 | - |
dc.identifier.issn | 1532-4303 | - |
dc.identifier.uri | http://www.tandfonline.com/doi/abs/10.3109/02770903.2010.529223?journalCode=ijas20 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/55112 | - |
dc.description.abstract | Background. Epidemiological studies have shown that obesity/adiposity is closely associated with asthma in terms of development, severity, and control of asthma. However, effects of obesity/adiposity on airway inflammation are not well known in subjects without asthma. We assessed whether fractional exhaled nitric oxide (FeNO), a marker of eosinophilic airway inflammation, was associated with obesity/adiposity in nonasthmatic healthy adults. Methods. We measured FeNO and serum levels of adipose-derived hormones and adipokines in 117 adult subjects without a previous diagnosis of asthma or current asthmatic symptoms. Associations between FeNO and measures of obesity/adiposity [body mass index (BMI), body fat mass, and body fat percentages] were examined by correlation analyses and uni- and multivariate linear regression analyses. Results. FeNO was not significantly associated with BMI, body fat mass, or body fat percentage by a multivariate linear regression model, adjusting for age, gender, chronic rhinitis, atopy, and lung function. No significant association of FeNO with serum levels of leptin, adiponectin, tumor necrosis factor (TNF)-α, or interleukin (IL)-6 was observed. Conclusions. These findings suggest that in healthy subjects without asthma, obesity/adiposity has no significant effect on eosinophilic airway inflammation and that hormones and systemic inflammation derived from adipose tissue do not affect eosinophilic airway inflammation. | en_US |
dc.description.sponsorship | This study was supported by a grant from the Korea Healthcare technology R&D project, Ministry of Health and Welfare, Republic of Korea (A040153). | en_US |
dc.language.iso | en | en_US |
dc.publisher | Informa Healthcare | en_US |
dc.subject | adipokines | en_US |
dc.subject | adipose-derived hormones | en_US |
dc.subject | adiposity | en_US |
dc.subject | airway inflammation | en_US |
dc.subject | body mass index | en_US |
dc.subject | exhaled nitric oxide | en_US |
dc.title | Adiposity, Adipokines, and Exhaled Nitric Oxide in Healthy Adults Without Asthma | en_US |
dc.type | Article | en_US |
dc.relation.no | 2 | - |
dc.relation.volume | 48 | - |
dc.identifier.doi | 10.3109/02770903.2010.529223 | - |
dc.relation.page | 177-182 | - |
dc.relation.journal | JOURNAL OF ASTHMA | - |
dc.contributor.googleauthor | Kim, Sang Heon | - |
dc.contributor.googleauthor | Kim, Tae Hyung | - |
dc.contributor.googleauthor | Lee, Ji Seon | - |
dc.contributor.googleauthor | Koo, Tai Yeon | - |
dc.contributor.googleauthor | Lee, Chang Beom | - |
dc.contributor.googleauthor | Yoon, Ho Joo | - |
dc.contributor.googleauthor | Shin, Dong Ho | - |
dc.contributor.googleauthor | Park, Sung Soo | - |
dc.contributor.googleauthor | Sohn, Jang Won | - |
dc.relation.code | 2011204696 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | hjyoon | - |
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