Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이종민 | - |
dc.date.accessioned | 2018-03-29T08:20:56Z | - |
dc.date.available | 2018-03-29T08:20:56Z | - |
dc.date.issued | 2014-01 | - |
dc.identifier.citation | JOURNAL OF ALZHEIMERS DISEASE, 2014, 41(1), p.169-178 | en_US |
dc.identifier.issn | 1387-2877 | - |
dc.identifier.uri | https://content.iospress.com/articles/journal-of-alzheimers-disease/jad132333 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/53877 | - |
dc.description.abstract | Background: The most-widely used visual rating scale (VRS) for medial temporal atrophy is the T1-weighted (T1W) coronal VRS developed by Scheltens et al. However, it is often difficult to use the T1W-coronal VRS in cases with limitations in obtaining T1W-coronal images. To overcome this issue, we modified the T1W-coronal VRS onto the axial plane. Objective: The purposes of this study were to validate our T1W-axial VRS by examining its compatibility with the original T1W-coronal VRS and by investigating the correlation with the cognitive functions and hippocampal volumes. Methods: Participants were 50 patients with Alzheimer's disease dementia and 30 elderly with normal cognition. We transposed each component of the T1W-coronal VRS onto T1W-axial images (i.e., the largest height of the hippocampal formation into the width of the medial temporal lobe). The compatibility of T1W-axial VRS with T1W-coronal one was determined using the kappa value. The correlations of T1W-axial VRS with cognitive performance or the hippocampal volumes were analyzed with age, gender, and education as covariates. Results: The kappa value between the T1W-axial and T1W-coronal VRS was 0.772 (p < 0.045). The T1W-axial VRS showed a significant correlation with the scores of cognitive functions, including verbal memory tests (-0.601, p < 0.001 for the left). Furthermore, the T1W-axial VRS also correlated well with hippocampal volumes (-0.576, p < 0.001). Conclusions: The T1W-axial VRS showed good agreement with T1W-coronal VRS and correlated well with cognitive functions as well as hippocampal volumes, which suggests that the T1-axial VRS may replace the original T1W-coronal one. | en_US |
dc.description.sponsorship | This study was supported by a grant from the Korean Healthcare Technology R&D Project, the Ministry for Health, Welfare & Family Affairs, Republic of Korea (HI10C2020). Authors’ disclosures available online (http://www.jalz.com/disclosures/view.php?id=2109). | en_US |
dc.language.iso | en | en_US |
dc.publisher | IOS PRESS | en_US |
dc.subject | Alzheimer's disease | en_US |
dc.subject | medial temporal atrophy | en_US |
dc.subject | visual rating scale | en_US |
dc.title | T1-weighted Axial Visual Rating Scale for an Assessment of Medial Temporal Atrophy in Alzheimer's Disease | en_US |
dc.type | Article | en_US |
dc.relation.no | 1 | - |
dc.relation.volume | 41 | - |
dc.identifier.doi | 10.3233/JAD-132333 | - |
dc.relation.page | 169-178 | - |
dc.relation.journal | JOURNAL OF ALZHEIMERS DISEASE | - |
dc.contributor.googleauthor | Kim, Geon Ha | - |
dc.contributor.googleauthor | Kim, Jung-Eun | - |
dc.contributor.googleauthor | Choi, Kyoung-Gyu | - |
dc.contributor.googleauthor | Jeong, Jee Hyang | - |
dc.contributor.googleauthor | Lim, Soo Mee | - |
dc.contributor.googleauthor | Lee, Jong-Min | - |
dc.contributor.googleauthor | Na, Duk L. | - |
dc.relation.code | 2014032293 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF ENGINEERING[S] | - |
dc.sector.department | DIVISION OF ELECTRICAL AND BIOMEDICAL ENGINEERING | - |
dc.identifier.pid | ljm | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.