Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 유혜현 | - |
dc.date.accessioned | 2018-03-27T00:07:56Z | - |
dc.date.available | 2018-03-27T00:07:56Z | - |
dc.date.issued | 2016-04 | - |
dc.identifier.citation | JOURNAL OF GINSENG RESEARCH, v. 40, No. 2, Page. 135-140 | en_US |
dc.identifier.issn | 1226-8453 | - |
dc.identifier.issn | 2093-4947 | - |
dc.identifier.uri | http://www.ginsengres.com/article/S1226-8453(15)00067-6/abstract | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/52773 | - |
dc.description.abstract | Background: Nephrotoxicity is a common side effect of medications. Panax ginseng is one of the best-known herbal medicines, and its individual constituents enhance renal function. Identification of its efficacy and mechanisms of action against drug-induced nephrotoxicity, as well as the specific constituents mediating this effect, have recently emerged as an interesting research area focusing on the kidney protective efficacy of P. ginseng. Methods: The present study investigated the kidney protective effect of fermented black ginseng (FBG) and its active component ginsenoside 20(S)-Rg3 against cisplatin (chemotherapy drug)-induced damage in pig kidney (LLC-PK1) cells. It focused on assessing the role of mitogen-activated protein kinases as important mechanistic elements in kidney protection. Results: The reduced cell viability induced by cisplatin was significantly recovered with FBG extract and ginsenoside 20(S)-Rg3 dose-dependently. The cisplatin-induced elevated protein levels of phosphorylated c-Jun N-terminal kinase (JNK), p53, and cleaved caspase-3 were decreased after cotreatment with FBG extract or ginsenoside 20(S)-Rg3. The elevated percentage of apoptotic LLC-PK1 cells induced by cisplatin treatment was significantly abrogated by cotreatment with FBG and the ginsenoside 20(S)-Rg3. Conclusion: FBG and its major ginsenoside 20(S)-Rg3, ameliorated cisplatin-induced nephrotoxicity in LLC-PK1 cells by blocking the JNK-p53-caspase-3 signaling cascade. Copyright 2015, The Korean Society of Ginseng, Published by Elsevier. | en_US |
dc.description.sponsorship | This research was funded by the Gangneung Asan Hospital Biomedical Research Center Promotion Fund. It was also supported by the Korea Institute of Science and Technology Institutional Program (2Z04371). | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | KOREAN SOC GINSENG | en_US |
dc.subject | cisplatin | en_US |
dc.subject | ginsenoside 20(S)-Rg3 | en_US |
dc.subject | mitogen-activated protein kinases | en_US |
dc.subject | nephrotoxicity | en_US |
dc.subject | Panax ginseng | en_US |
dc.title | Beneficial effects of fermented black ginseng and its ginsenoside 20(S)-Rg3 against cisplatin-induced nephrotoxicity in LLC-PK1 cells | en_US |
dc.type | Article | en_US |
dc.relation.no | 2 | - |
dc.relation.volume | 40 | - |
dc.identifier.doi | 10.1016/j.jgr.2015.06.006 | - |
dc.relation.page | 135-140 | - |
dc.relation.journal | JOURNAL OF GINSENG RESEARCH | - |
dc.contributor.googleauthor | Han, Myoung-Sik | - |
dc.contributor.googleauthor | Han, Im-Ho | - |
dc.contributor.googleauthor | Lee, Dahae | - |
dc.contributor.googleauthor | An, Jun Min | - |
dc.contributor.googleauthor | Kim, Su-Nam | - |
dc.contributor.googleauthor | Shin, Myoung-Sook | - |
dc.contributor.googleauthor | Yamabe, Noriko | - |
dc.contributor.googleauthor | Hwang, Gwi Seo | - |
dc.contributor.googleauthor | Yoo, Hye Hyun | - |
dc.contributor.googleauthor | Choi, Suk-Jung | - |
dc.contributor.googleauthor | Kang, Ki Sung | - |
dc.contributor.googleauthor | Jang, Hyuk-Jai | - |
dc.relation.code | 2016009954 | - |
dc.sector.campus | E | - |
dc.sector.daehak | COLLEGE OF PHARMACY[E] | - |
dc.sector.department | DEPARTMENT OF PHARMACY | - |
dc.identifier.pid | yoohh | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.