Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김선정 | - |
dc.date.accessioned | 2018-03-25T07:07:19Z | - |
dc.date.available | 2018-03-25T07:07:19Z | - |
dc.date.issued | 2013-02 | - |
dc.identifier.citation | Basic & Clinical Pharmacology & Toxicology, Feb 2013, 112(2), P.83-89 | en_US |
dc.identifier.issn | 1742-7835 | - |
dc.identifier.uri | https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1742-7843.2012.00929.x | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/51948 | - |
dc.description.abstract | Transient receptor potential melastatin 7 (TRPM7) plays a role in a number of physiological and pharmacological functions in variety of cells. The aim of this study was to clarify the role for TRPM7 channels and the effect of waixenicin A on the pacemaking activity of interstitial cells of Cajal (ICCs) and on the cell viability of the human gastric and breast adenocarcinoma cell lines, AGS and MCF-7, respectively. Waixenicin A decreased the amplitude of pacemaker potentials in cultured ICC clusters and inhibited TRPM7 currents, but had no effect on Ca2+-activated Cl- conductance (ANO1). Furthermore, waixenicin A was found to inhibit the growth and survival of AGS and MCF-7 cells. These findings indicate that TRPM7 channel modulates intestinal motility and regulates the pathophysiology of human gastric and breast adenocarcinoma cells. These findings suggest that TRPM7 channel be considered a potential target for the treatment of gut motor disorders and gastric and breast cancer. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Wiley-Blackwell | en_US |
dc.subject | INTERSTITIAL-CELLS | en_US |
dc.subject | ELECTRICAL RHYTHMICITY | en_US |
dc.subject | GASTROINTESTINAL-TRACT | en_US |
dc.subject | TRPM7 CHANNELS | en_US |
dc.subject | ION CHANNELS | en_US |
dc.subject | CANCER | en_US |
dc.subject | CAJAL | en_US |
dc.subject | PROLIFERATION | en_US |
dc.subject | MAGNESIUM | en_US |
dc.subject | CALCIUM | en_US |
dc.title | The Role of Waixenicin A as Transient Receptor Potential Melastatin 7 Blocker | en_US |
dc.type | Article | en_US |
dc.relation.no | 2 | - |
dc.relation.volume | 112 | - |
dc.identifier.doi | 10.1111/j.1742-7843.2012.00929.x | - |
dc.relation.page | 83-89 | - |
dc.relation.journal | BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY | - |
dc.contributor.googleauthor | Kim, B. J. | - |
dc.contributor.googleauthor | Nam, J. H. | - |
dc.contributor.googleauthor | Kwon, Y. K. | - |
dc.contributor.googleauthor | So, I. | - |
dc.contributor.googleauthor | Kim, S. J. | - |
dc.relation.code | 2013009084 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF ENGINEERING[S] | - |
dc.sector.department | DIVISION OF ELECTRICAL AND BIOMEDICAL ENGINEERING | - |
dc.identifier.pid | sjk | - |
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