Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 이수재 | - |
dc.date.accessioned | 2018-03-24T06:09:49Z | - |
dc.date.available | 2018-03-24T06:09:49Z | - |
dc.date.issued | 2014-02 | - |
dc.identifier.citation | IUBMB LIFE; FEB 2014, 66, 2, p128-p137 | en_US |
dc.identifier.issn | 1521-6543 | - |
dc.identifier.uri | https://iubmb.onlinelibrary.wiley.com/doi/full/10.1002/iub.1248 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/51839 | - |
dc.description.abstract | Although low-dose radiation (LDR) regulates a wide range of biological processes, limited information is available on the effects of LDR on the chondrocyte phenotype. Here, we found that LDR, at doses of 0.5-2 centiGray (cGy), inhibited interleukin (IL)-1 beta-induced chondrocyte destruction without causing side effects, such as cell death and senescence. IL-1 beta treatment induced an increase in the expression of alpha-, beta-, and gamma-catenin proteins in chondrocytes via Akt signaling, thereby promoting dedifferentiation through catenin-dependent suppression of Sox-9 transcription factor expression and induction of inflammation through activation of the NF-kappa B pathway. Notably, LDR blocked cartilage disorders by inhibiting IL-1 beta-induced catenin signaling and subsequent catenin-dependent suppression of the Sox-9 pathway and activation of the NF-kappa B pathway, without directly altering catenin expression. LDR also inhibited chondrocyte destruction through the catenin pathway induced by epidermal growth factor, phorbol 12-myristate 13-acetate, and retinoic acid. Collectively, these results identify the molecular mechanisms by which LDR suppresses pathophysiological processes and establish LDR as a potentially valuable therapeutic tool for patients with cytokine- or soluble factors-mediated cartilage disorders. (c) 2014 The Authors IUBMB Life published by Wiley Periodicals, Inc. on behalf of International Union of Biochemistry and Molecular Biology, 66(2):128-137, 2014 | en_US |
dc.description.sponsorship | This work was supported by the Nuclear Research & Development Program of the National Research Foundation and by the Nuclear Energy Technology Innovation Program of the Korea Institute of Energy Technology Evaluation Planning (No. SUBJID?0000000015133). | en_US |
dc.language.iso | en | en_US |
dc.publisher | WILEY-BLACKWELL | en_US |
dc.subject | inflammation | en_US |
dc.subject | catenin | en_US |
dc.subject | dedifferentiation | en_US |
dc.subject | low dose radiation | en_US |
dc.subject | chondrocytes | en_US |
dc.title | Low-dose gamma-radiation inhibits IL-1 beta-induced dedifferentiation and inflammation of articular chondrocytes via blockage of catenin signaling | en_US |
dc.type | Article | en_US |
dc.relation.volume | 66 | - |
dc.identifier.doi | 10.1002/iub.1248 | - |
dc.relation.page | 128-137 | - |
dc.relation.journal | IUBMB LIFE | - |
dc.contributor.googleauthor | Hong, Eun-Hee | - |
dc.contributor.googleauthor | Song, Jie-Young | - |
dc.contributor.googleauthor | Park, In-Chul | - |
dc.contributor.googleauthor | Um, Hong-Duck | - |
dc.contributor.googleauthor | Park, Jong Kuk | - |
dc.contributor.googleauthor | Lee, Kee-Ho | - |
dc.contributor.googleauthor | Hwang, Sang-Gu | - |
dc.contributor.googleauthor | Lee, Su-Jae | - |
dc.contributor.googleauthor | Nam, Seon Young | - |
dc.relation.code | 2014032075 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF NATURAL SCIENCES[S] | - |
dc.sector.department | DEPARTMENT OF LIFE SCIENCE | - |
dc.identifier.pid | sj0420 | - |
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