Elevated A1C is associated with impaired early-phase insulin secretion rather than insulin resistance in Koreans at high risk for developing diabetes
- Title
- Elevated A1C is associated with impaired early-phase insulin secretion rather than insulin resistance in Koreans at high risk for developing diabetes
- Author
- 박용수
- Keywords
- Pre-diabetes; Impaired glucose tolerance; Impaired fasting glucose; Insulinogenic index; HOMA-IR; Metabolic syndrome
- Issue Date
- 2012-12
- Publisher
- Springer Science + Business Media
- Citation
- ENDOCRINE -BASINGSTOKE-, 2012, 42(3), P.584-591
- Abstract
- The purpose of this study is to examine the association of A1C with beta-cell dysfunction, insulin resistance, and cardiovascular risk factors in Koreans with the relatively high risk for the future development of diabetes. This cross-sectional study recruited subjects from the pre-diabetic cohort of the Korea National Diabetes Program. Among study subjects (n = 616) aged 21-77 years with a history of hyperglycemia (fasting plasma glucose (FPG) a parts per thousand yen5.5 mmol/mL), analyses were conducted on 504 participants (296 women, 208 men) except for subjects with FPG a parts per thousand yen 7.0 mmol/L or 120-min post-challenge plasma glucose a parts per thousand yen11.1 mmol/L or A1C a parts per thousand yen 6.5 %. For insulin sensitivity and beta-cell function classified by the categories of A1C levels, a dagger Ins(30-0)/a dagger Glu(30-0) was lower in the highest quartile group than other groups. Although there was no significant difference in HOMA-IR according to the A1C categories, even lowest A1C group (a parts per thousand currency sign5.3 %) already included many subjects with abnormal glucose tolerance. A1C showed a significant association with hsCRP, number of metabolic syndrome (MetS) components and a dagger Ins(30-0)/a dagger Glu(30-0) after adjusting for age, gender, BMI, and medications whereas HOMA-IR was insignificantly associated with A1C. Stepwise regression analysis for A1C showed that A1C is independently and negatively associated with a dagger Ins(30-0)/a dagger Glu(30-0), and positively associated with hsCRP. Our study showed that higher A1C was associated with impaired early-phase insulin secretion, MetS, and low grade inflammation in Koreans with the relatively high risk for the future development of diabetes.
- URI
- https://link.springer.com/article/10.1007%2Fs12020-012-9666-3http://hdl.handle.net/20.500.11754/48356
- ISSN
- 1355-008X
- DOI
- 10.1007/s12020-012-9666-3
- Appears in Collections:
- COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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