Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 박용수 | - |
dc.date.accessioned | 2018-03-17T06:12:04Z | - |
dc.date.available | 2018-03-17T06:12:04Z | - |
dc.date.issued | 2012-12 | - |
dc.identifier.citation | ENDOCRINE -BASINGSTOKE-, 2012, 42(3), P.584-591 | en_US |
dc.identifier.issn | 1355-008X | - |
dc.identifier.uri | https://link.springer.com/article/10.1007%2Fs12020-012-9666-3 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/48356 | - |
dc.description.abstract | The purpose of this study is to examine the association of A1C with beta-cell dysfunction, insulin resistance, and cardiovascular risk factors in Koreans with the relatively high risk for the future development of diabetes. This cross-sectional study recruited subjects from the pre-diabetic cohort of the Korea National Diabetes Program. Among study subjects (n = 616) aged 21-77 years with a history of hyperglycemia (fasting plasma glucose (FPG) a parts per thousand yen5.5 mmol/mL), analyses were conducted on 504 participants (296 women, 208 men) except for subjects with FPG a parts per thousand yen 7.0 mmol/L or 120-min post-challenge plasma glucose a parts per thousand yen11.1 mmol/L or A1C a parts per thousand yen 6.5 %. For insulin sensitivity and beta-cell function classified by the categories of A1C levels, a dagger Ins(30-0)/a dagger Glu(30-0) was lower in the highest quartile group than other groups. Although there was no significant difference in HOMA-IR according to the A1C categories, even lowest A1C group (a parts per thousand currency sign5.3 %) already included many subjects with abnormal glucose tolerance. A1C showed a significant association with hsCRP, number of metabolic syndrome (MetS) components and a dagger Ins(30-0)/a dagger Glu(30-0) after adjusting for age, gender, BMI, and medications whereas HOMA-IR was insignificantly associated with A1C. Stepwise regression analysis for A1C showed that A1C is independently and negatively associated with a dagger Ins(30-0)/a dagger Glu(30-0), and positively associated with hsCRP. Our study showed that higher A1C was associated with impaired early-phase insulin secretion, MetS, and low grade inflammation in Koreans with the relatively high risk for the future development of diabetes. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Springer Science + Business Media | en_US |
dc.subject | Pre-diabetes | en_US |
dc.subject | Impaired glucose tolerance | en_US |
dc.subject | Impaired fasting glucose | en_US |
dc.subject | Insulinogenic index | en_US |
dc.subject | HOMA-IR | en_US |
dc.subject | Metabolic syndrome | en_US |
dc.title | Elevated A1C is associated with impaired early-phase insulin secretion rather than insulin resistance in Koreans at high risk for developing diabetes | en_US |
dc.type | Article | en_US |
dc.relation.no | 3 | - |
dc.relation.volume | 42 | - |
dc.identifier.doi | 10.1007/s12020-012-9666-3 | - |
dc.relation.page | 584-591 | - |
dc.relation.journal | ENDOCRINE | - |
dc.contributor.googleauthor | Kim, Tae Nyun | - |
dc.contributor.googleauthor | Park, Man Sik | - |
dc.contributor.googleauthor | Lee, Seong Keon | - |
dc.contributor.googleauthor | Yang, Sae Jeong | - |
dc.contributor.googleauthor | Lee, Kwan Woo | - |
dc.contributor.googleauthor | Nam, Moon Suk | - |
dc.contributor.googleauthor | Park, Yong Soo | - |
dc.contributor.googleauthor | Woo, Jeong Taek | - |
dc.contributor.googleauthor | Kim, Young Seol | - |
dc.contributor.googleauthor | Baik, Sei Hyun | - |
dc.relation.code | 2012202811 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | parkys | - |
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