Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 송이선 | - |
dc.date.accessioned | 2018-03-16T07:32:49Z | - |
dc.date.available | 2018-03-16T07:32:49Z | - |
dc.date.issued | 2014-04 | - |
dc.identifier.citation | Cardiovascular Drugs and Therapy, 2014, 28(3), P.211-220 | en_US |
dc.identifier.issn | 0920-3206 | - |
dc.identifier.uri | https://link.springer.com/article/10.1007/s10557-014-6519-8 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/48081 | - |
dc.description.abstract | In recent studies, granulocyte-colony stimulating factor (G-CSF) was shown to improve cardiac function in myocardial infarction and non-ischemic cardiomyopathies. The mechanisms of these beneficial effects of G-CSF in diabetic cardiomyopathy are not yet fully understood. Therefore, we investigated the mechanisms of action of G-CSF on diabetic cardiomyopathy in a rat model of type 2 diabetes.Seventeen-week-old OLETF (Otsuka Long Evans Tokushima Fatty) diabetic rats and LETO (Long Evans Tokushima Otuska) rats were randomized to treatment with 5 days of G-CSF (100 mu g/kg/day) or with saline. Cardiac function was evaluated by serial echocardiography performed before and 4 weeks after treatment. We measured expression of the G-CSF receptor (GCSFR) and Bcl-2, as well as the extent of apoptosis in the myocardium.G-CSF treatment significantly improved cardiac diastolic function in the serial echocardiography assessments. Expression of G-CSFR was down-regulated in the diabetic myocardium (0.03 +/- 0.12 % vs. 1 +/- 0.15 %, p < 0.05), and its expression was stimulated by G-CSF treatment (0.03 +/- 0.12 % vs. 0.42 +/- 0.06 %, p < 0.05). In addition, G-CSF treatment increased the expression of Bcl-2 in the diabetic myocardium (0.69 +/- 0.06 % vs. 0.26 +/- 0.11 %, p < 0.05), consistent with the reduced cardiomyocyte apoptosis (9.38 +/- 0.67 % vs. 17.28 +/- 2.16 %, p < 0.05).Our results suggest that G-CSF might have a cardioprotective effect in diabetic cardiomyopathy through up-regulation of G-CSFR, attenuation of apoptosis by up-regulation of Bcl-2 expression, and glucose-lowering effect. Our findings support the therapeutic potential of G-CSF in diabetic cardiomyopathy. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Springer | en_US |
dc.subject | Apoptosis | en_US |
dc.subject | Diabetic cardiomyopathy | en_US |
dc.subject | G-CSF | en_US |
dc.title | Granulocyte-Colony Stimulating Factor Reduces Cardiomyocyte Apoptosis and Ameliorates Diastolic Dysfunction in Otsuka Long-Evans Tokushima Fatty Rats | en_US |
dc.type | Article | en_US |
dc.relation.no | 3 | - |
dc.relation.volume | 28 | - |
dc.identifier.doi | 10.1007/s10557-014-6519-8 | - |
dc.relation.page | 211-220 | - |
dc.relation.journal | CARDIOVASCULAR DRUGS AND THERAPY | - |
dc.contributor.googleauthor | Shin, J. H. | - |
dc.contributor.googleauthor | Lim, Y. H. | - |
dc.contributor.googleauthor | Song, Y. S. | - |
dc.contributor.googleauthor | So, B. I. | - |
dc.contributor.googleauthor | Park, J. Y. | - |
dc.contributor.googleauthor | Fang, C. H. | - |
dc.contributor.googleauthor | Lee, Y. | - |
dc.contributor.googleauthor | Kim, H. | - |
dc.contributor.googleauthor | Kim, K. S. | - |
dc.relation.code | 2014026873 | - |
dc.sector.campus | S | - |
dc.sector.daehak | RESEARCH INSTITUTE[S] | - |
dc.sector.department | INSTITUTE FOR THE INTERGRATION OF MEDICINE AND INNOVATIVE TECHNOLOGY | - |
dc.identifier.pid | yisun486 | - |
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