Ene-hydrazide from Enol Triflate for the Regioselective Fischer Indole Synthesis
- Title
- Ene-hydrazide from Enol Triflate for the Regioselective Fischer Indole Synthesis
- Author
- 조천규
- Keywords
- ENANTIOSELECTIVE SYNTHESIS; COUPLING REACTIONS; ARYL HYDRAZIDES; DERIVATIVES; YSTEM; EARRANGEMENT; COMBINATION; BROMIDES; IODIDES; HALIDES
- Issue Date
- 2014-08
- Publisher
- AMER CHEMICAL SOC
- Citation
- ORGANIC LETTERS, 2014, 16(17), p.4492-4495
- Abstract
- Ene-hydrazide prepared from enol triflate undergoes a Fischer indolization reaction to give the corresponding indole with complete regioselectivity. The starting enol triflate is readily accessed in regiochemically defined form from the ketone precursor via various well-established methods. This new protocol was successfully applied to the synthesis of desbromoarborescidine A, a natural beta-carboline alkaloid, difficult to prepare with conventional Fischer indole synthesis.
- URI
- https://pubs.acs.org/doi/10.1021/ol502031qhttp://hdl.handle.net/20.500.11754/47197
- ISSN
- 1523-7060; 1523-7052
- DOI
- 10.1021/ol502031q
- Appears in Collections:
- COLLEGE OF NATURAL SCIENCES[S](자연과학대학) > CHEMISTRY(화학과) > Articles
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