Clinicopathologic factors for central recurrence in patients with locally advanced bulky cervical cancer
- Title
- Clinicopathologic factors for central recurrence in patients with locally advanced bulky cervical cancer
- Author
- 이원무
- Keywords
- Uterine cervical neoplasm; Recurrence; Local neoplasm recurrence; Adjuvant hysterectomy
- Issue Date
- 2012-04
- Publisher
- Elsevier Science B.V., Amsterdam.
- Citation
- European Journal of Obstetrics & Gynecology and Reproductive Biology, 2012, 161(2), P.219-223
- Abstract
- Objective: Locally advanced bulky cervical cancer (LABCC) is characterized by poor local control. The objective of this study was to identify the clinicopathologic variables associated with one-year central-only recurrence, which will serve as criteria for adjuvant hysterectomy after radiation (AHR) in patients with LABCC. Study design: Between January 2000 and August 2007, we retrospectively evaluated outcomes in 225 patients with LABCC who were initially treated with radiation or chemoradiation. Results: Among the 225 patients with LABCC, there were 41 recurrences within one year after treatment (8 central-only and 33 pelvis and/or distant site recurrences). Age, stage, and treatment type were not associated with the one-year central-only recurrences, but tumor size >= 8 cm had a statistically significant association based on multivariate analysis (OR, 5.39; 95% CI, 1.15-25.31; p = 0.03). The combination of non-squamous cell (non-SCC) type and tumor size >= 8 cm had a significantly higher rate of recurrence within one year (OR, 43.0; 95% CI, 4.78-386.68; p < 0.01). Conclusions: Of patients with LABCC, those with non-SCC tumors >= 8 cm in size were at high risk for early central-only recurrence after cisplatin-based chemoradiation, and represent the subset of patients for whom AHR is beneficial. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
- URI
- http://www.ejog.org/article/S0301-2115(12)00007-3/fulltexthttp://hdl.handle.net/20.500.11754/46988
- ISSN
- 0301-2115
- DOI
- 10.1016/j.ejogrb.2011.12.029
- Appears in Collections:
- COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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