Optimal precurarizing dose of rocuronium to decrease fasciculation and myalgia following succinylcholine administration
- Title
- Optimal precurarizing dose of rocuronium to decrease fasciculation and myalgia following succinylcholine administration
- Author
- 김교상
- Keywords
- Fasciculation; Myalgia; Neuromuscular blockade; Precurarization; Rocuronium; Succinylcholine.
- Issue Date
- 2014-06
- Publisher
- Korean Society Of Anesthesiologists
- Citation
- Korean Journal of Anesthesiology, 권: 66, 호: 6, 페이지: 451-456
- Abstract
- Background: Succinylcholine commonly produces frequent adverse effects, including muscle fasciculation and myalgia. The current study identified the optimal dose of rocuronium to prevent succinylcholine-induced fasciculation and myalgia and evaluated the influence of rocuronium on the speed of onset produced by succinylcholine.Methods: This randomized, double-blinded study was conducted in 100 patients randomly allocated into five groups of 20 patients each. Patients were randomized to receive 0.02, 0.03, 0.04, 0.05 and 0.06 mg/kg rocuronium as a precurarizing dose. Neuromuscular monitoring after each precurarizing dose was recorded from the adductor pollicis muscle using acceleromyography with train-of-four stimulation of the ulnar nerve. All patients received succinylcholine 1.5 mg/kg at 2 minutes after the precurarization, and were assessed the incidence and severity of fasciculations, while myalgia was assessed at 24 hours after surgery.Results: The incidence and severity of visible muscle fasciculation was significantly less with increasing the amount of precurarizing dose of rocuronium (P < 0.001). Those of myalgia tend to decrease according to increasing the amount of precurarizing dose of rocuronium, but there was no significance (P = 0.072). The onset time of succinylcholine was significantly longer with increasing the amount of precurarizing dose of rocuronium (P < 0.001).Conclusions: Precurarization with 0.04 mg/kg rocuronium was the optimal dose considering the reduction in the incidence and severity of fasciculation and myalgia with acceptable onset time, and the safe and effective precurarization.
- URI
- https://ekja.org/journal/view.php?doi=10.4097/kjae.2014.66.6.451http://hdl.handle.net/20.500.11754/46491
- ISSN
- 2005-6419
- DOI
- 10.4097/kjae.2014.66.6.451
- Appears in Collections:
- COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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