Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 임승순 | - |
dc.date.accessioned | 2018-03-13T05:10:39Z | - |
dc.date.available | 2018-03-13T05:10:39Z | - |
dc.date.issued | 2013-06 | - |
dc.identifier.citation | Macromolecular Research, November , 2013, 21(11), P.1281-1288 | en_US |
dc.identifier.issn | 1598-5032 | - |
dc.identifier.uri | https://link.springer.com/article/10.1007/s13233-013-1178-3 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/45921 | - |
dc.description.abstract | The goal of this study was to prepare functionalized, ultrathin nanofibers using mesoporous materials (TS-1 zeolite) with maximum capability to both absorb drug and control drug release (these fibers are herein referred to as PZ-01); a second goal was to prepare nanofibers that exhibit biodegradability after drug release. Under optimal conditions, the characteristic of TS-1 zeolite enabled the preparation of ultrathin nanofibers with diameters below 100 nm, or one-twentieth the size of homo-poly(butylene succinate) (PBS) fibers. In addition, PZ-01 nanofibers exhibited high drug loading capacity compared to homo-PBS fibers. This result was attributable to the large surface area of ultrathin nanofibers and to the strong ionic interaction between hydrophilic drugs and the metal ions of TS-1 zeolite. In vitro cytostatic assay indicated that prepared PZ-01 has cytostatic action toward both Gram-positive and Gram-negative bacteria. The excellent drug wetting behavior of PZ-01 led to longer drug-release times. After drugrelease tests, antibacterial tests confirmed that homo-PBS fibers had diminished antibiotic activity regardless of the type of bacteria, whereas the antibacterial activity of tested PZ-01 was highly efficient against both Gram-positive and Gram-negative bacteria. In the cell viability test, PZ-01 exhibited a greater decrease in cytotoxicity and an increase in cell viability compared with the homo-PBS nanofiber. Based on this research, we anticipate that these materials will be promising candidates for biomedical applications such as biofilters for microbes, wound dressings, and drug-delivery products | en_US |
dc.language.iso | en | en_US |
dc.publisher | THE POLYMER SOCIETY OF KOREA | en_US |
dc.subject | biomedical polymer | en_US |
dc.subject | controlled release | en_US |
dc.subject | drug delivery | en_US |
dc.subject | microbial materials | en_US |
dc.subject | TS-1 zeolite | en_US |
dc.subject | ultrathin nanofiber | en_US |
dc.title | Fabrication of superabsorbent ultrathin nanofibers using mesoporous materials for antimicrobial drug-delivery applications | en_US |
dc.type | Article | en_US |
dc.relation.volume | 21 | - |
dc.identifier.doi | 10.1007/s13233-013-1178-3 | - |
dc.relation.page | 1281-1288 | - |
dc.relation.journal | MACROMOLECULAR RESEARCH | - |
dc.contributor.googleauthor | Hwang, S. Y | - |
dc.contributor.googleauthor | Yoon, W. J. | - |
dc.contributor.googleauthor | Yun, S. H | - |
dc.contributor.googleauthor | Yoo, E. S | - |
dc.contributor.googleauthor | Kim, T. H. | - |
dc.contributor.googleauthor | Im, S. S. | - |
dc.relation.code | 2013011179 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF ENGINEERING[S] | - |
dc.sector.department | DEPARTMENT OF ORGANIC AND NANO ENGINEERING | - |
dc.identifier.pid | imss007 | - |
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