Injection pressure is one of factors that influence part quality. In this paper, injection pressure was minimized by optimizing valve gate locations. In order to perform design optimization, MAPS-3DTM (Mold Analysis and Plastic Solution-3D) was used for injection mold analysis and PIAnOTM (Process Integration, Automation and Optimization) was used as process integration and design optimization. Also we adapted meta models based on design of experiments for efficiency. By using introduced methodology, we were able to obtain a result so that maximum injection pressure reduced by 28% compared to the initial design. And the validity of the proposed method could also be demonstrated.