Unrelated donor cord blood transplantation for nonmalignant disorders in children and adolescents
- Title
- Unrelated donor cord blood transplantation for nonmalignant disorders in children and adolescents
- Author
- 이영호
- Keywords
- unrelated cord blood transplantation; non?malignant disease; children; adolescents
- Issue Date
- 2013-12
- Publisher
- Wiley
- Citation
- Pediatric Transplantation, 18권, 2호, 221p ~ 229p
- Abstract
- This study analyzes the data reported to the Korean Cord Blood Registry between 1994 and 2008, involving children and adolescents with non-malignant diseases. Sixty-five patients were evaluated in this study: SAA (n = 24), iBMFS, (n = 16), and primary immune deficiency/inherited metabolic disorder (n = 25). The CI of neutrophil recovery was 73.3% on day 42. By day 100, the CI of acute grade II?IV graft-versus-host disease was 32.3%. At a median follow-up of 71 months, five-yr OS was 50.7%. The survival rate (37.5%) and CI of neutrophil engraftment (37.5%) were lowest in patients with iBMFS. Deaths were mainly due to infection, pulmonary complications, and hemorrhage. In a multivariate analysis, the presence of >3.91 × 105/kg of infused CD34 + cells was the only factor consistently identified as significantly associated with neutrophil engraftment (p = 0.04) and OS (p = 0.03). UCBT using optimal cell doses appears to be a feasible therapy for non-malignant diseases in children and adolescents for whom there is no appropriate HLA-matched related donor. Strategies to reduce transplant-related toxicities would improve the outcomes of UCBT in non-malignant diseases.
- URI
- http://onlinelibrary.wiley.com/doi/10.1111/petr.12213/abstracthttp://hdl.handle.net/20.500.11754/45176
- ISSN
- 1397-3142; 1399-3046
- DOI
- 10.1111/petr.12213
- Appears in Collections:
- COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
- Files in This Item:
There are no files associated with this item.
- Export
- RIS (EndNote)
- XLS (Excel)
- XML