Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이영호 | - |
dc.date.accessioned | 2018-03-12T02:47:14Z | - |
dc.date.available | 2018-03-12T02:47:14Z | - |
dc.date.issued | 2013-12 | - |
dc.identifier.citation | Pediatric Transplantation, 18권, 2호, 221p ~ 229p | en_US |
dc.identifier.issn | 1397-3142 | - |
dc.identifier.issn | 1399-3046 | - |
dc.identifier.uri | http://onlinelibrary.wiley.com/doi/10.1111/petr.12213/abstract | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/45176 | - |
dc.description.abstract | This study analyzes the data reported to the Korean Cord Blood Registry between 1994 and 2008, involving children and adolescents with non-malignant diseases. Sixty-five patients were evaluated in this study: SAA (n = 24), iBMFS, (n = 16), and primary immune deficiency/inherited metabolic disorder (n = 25). The CI of neutrophil recovery was 73.3% on day 42. By day 100, the CI of acute grade II?IV graft-versus-host disease was 32.3%. At a median follow-up of 71 months, five-yr OS was 50.7%. The survival rate (37.5%) and CI of neutrophil engraftment (37.5%) were lowest in patients with iBMFS. Deaths were mainly due to infection, pulmonary complications, and hemorrhage. In a multivariate analysis, the presence of >3.91 × 105/kg of infused CD34 + cells was the only factor consistently identified as significantly associated with neutrophil engraftment (p = 0.04) and OS (p = 0.03). UCBT using optimal cell doses appears to be a feasible therapy for non-malignant diseases in children and adolescents for whom there is no appropriate HLA-matched related donor. Strategies to reduce transplant-related toxicities would improve the outcomes of UCBT in non-malignant diseases. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Wiley | en_US |
dc.subject | unrelated cord blood transplantation | en_US |
dc.subject | non?malignant disease | en_US |
dc.subject | children | en_US |
dc.subject | adolescents | en_US |
dc.title | Unrelated donor cord blood transplantation for nonmalignant disorders in children and adolescents | en_US |
dc.type | Article | en_US |
dc.relation.volume | 18 | - |
dc.identifier.doi | 10.1111/petr.12213 | - |
dc.relation.page | 221-229 | - |
dc.relation.journal | PEDIATRIC TRANSPLANTATION | - |
dc.contributor.googleauthor | Park, Meerim | - |
dc.contributor.googleauthor | Lee, Young Ho | - |
dc.contributor.googleauthor | Kang, Hae?Ryong | - |
dc.contributor.googleauthor | Lee, Ji Won | - |
dc.contributor.googleauthor | Kang, Hyoung Jin | - |
dc.contributor.googleauthor | Park, Kyung Duk | - |
dc.contributor.googleauthor | Shin, Hee Young | - |
dc.contributor.googleauthor | Ahn, Hyo Seop | - |
dc.contributor.googleauthor | Baek, Hee Jo | - |
dc.contributor.googleauthor | Kook, Hoon | - |
dc.relation.code | 2013006892 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | cord | - |
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