Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김영필 | - |
dc.date.accessioned | 2018-03-09T06:47:41Z | - |
dc.date.available | 2018-03-09T06:47:41Z | - |
dc.date.issued | 2013-04 | - |
dc.identifier.citation | MOLECULES AND CELLS, April 2013, 35(4), P.348-354 | en_US |
dc.identifier.issn | 1016-8478 | - |
dc.identifier.uri | http://link.springer.com/article/10.1007%2Fs10059-013-0021-1 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/44328 | - |
dc.description.abstract | Acteoside, an active phenylethanoid glycoside, has been used traditionally as an anti-inflammatory agent. The molecular mechanism by which acteoside reduces inflammation was investigated in lipopolysaccharide (LPS)-induced Raw264.7 cells and in a mouse model of cecal ligation and puncture (CLP)-induced sepsis. In vitro, acteoside inhibits high mobility group box 1 (HMGB1) release and iNOS/NO production and induces heme oxygenase-1 (HO-1) expression in a concentration-dependent manner, while HO-1 siRNA antagonizes the inhibition of HMGB1 and NO. The effect of acteoside is inhibited by the p38 mitogen-activated protein kinase (MAPK) inhibitor SB203580 and Nfr2 siRNA, indicating that acteoside induces HO-1 via p38 MAPK and NF-E2-related factor 2 (Nrf2). In vivo, acteoside increases survival and decreases serum and lung HMGB1 levels in CLP-induced sepsis. Overall, these results that acteoside reduces HMGB1 release and may be beneficial for the treatment of sepsis. | en_US |
dc.description.sponsorship | Basic Science Research Program through the National Research Foundation of Korea (NRF) Ministry of Education, Science and Technology Asan Institute for Life Sciences, Seoul, Korea | en_US |
dc.language.iso | en | en_US |
dc.publisher | KOREAN SOC MOLECULAR & CELLULAR BIOLOGY | en_US |
dc.subject | acteoside | en_US |
dc.subject | heme oxygenase 1 | en_US |
dc.subject | high-mobility group box 1 | en_US |
dc.subject | nrf2 | en_US |
dc.subject | p38 | en_US |
dc.subject | Raw264.7 cell | en_US |
dc.subject | sepsis | en_US |
dc.title | Acteoside improves survival in cecal ligation and puncture-induced septic mice via blocking of high mobility group box 1 release | en_US |
dc.type | Article | en_US |
dc.relation.no | 4 | - |
dc.relation.volume | 35 | - |
dc.identifier.doi | 10.1007/s10059-013-0021-1 | - |
dc.relation.page | 348-354 | - |
dc.relation.journal | MOLECULES AND CELLS | - |
dc.contributor.googleauthor | Seo, Eun Sun | - |
dc.contributor.googleauthor | Oh, Bo Kang | - |
dc.contributor.googleauthor | Pak, Jhang Ho | - |
dc.contributor.googleauthor | Yim, Soon-Ho | - |
dc.contributor.googleauthor | Gurunathan, Sangilyandi | - |
dc.contributor.googleauthor | Kim, Young-Pil | - |
dc.contributor.googleauthor | Lee, Kyung Jin | - |
dc.relation.code | 2013011359 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF NATURAL SCIENCES[S] | - |
dc.sector.department | DEPARTMENT OF LIFE SCIENCE | - |
dc.identifier.pid | ypilkim | - |
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