Hepatitis C virus Core protein overcomes all-trans retinoic acid-induced cell growth arrest by inhibiting retinoic acid receptor-beta(2) expression via DNA methylation
- Title
- Hepatitis C virus Core protein overcomes all-trans retinoic acid-induced cell growth arrest by inhibiting retinoic acid receptor-beta(2) expression via DNA methylation
- Author
- 최동호
- Keywords
- All-trans retinoic acid; DNA methylation; HCV Core; Retinoic acid receptor-beta(2); p16; TUMOR-SUPPRESSOR GENES; E-CADHERIN EXPRESSION; HEPATOCELLULAR-CARCINOMA; PROMOTER HYPOMETHYLATION; UP-REGULATION; CANCER CELLS; LUNG-CANCER; X PROTEIN; BETA; DIFFERENTIATION
- Issue Date
- 2013-07
- Publisher
- ELSEVIER IRELAND LTD, ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND
- Citation
- Cancer Letters, Vol.335, No.2 [2013], p372-379
- Abstract
- Aberrant promoter methylation of tumor suppressor genes including retinoic acid receptor-beta(2) (RAR-beta(2)) is frequently detected in hepatitis C virus (HCV)-associated hepatocellular carcinoma; however, the mechanism and its significance are relatively unknown. Here, we showed that HCV Core induced promoter hypermethylation of RAR-beta(2) to inhibit its expression via up-regulation of DNA methyltransferases 1 and 3b. Under the condition, all-trans retinoic acid (ATRA) failed to activate p16 expression and thus could not inactivate the Rb-E2F pathway. Accordingly, Core-expressing cells exhibited resistance to ATRA-induced growth inhibition. Taken together, HCV Core antagonizes ATRA, a natural anti-cancer compound, to stimulate cell growth via epigenetic down-regulation of RAR-beta(2). (C) 2013 Elsevier Ireland Ltd. All rights reserved.
- URI
- http://www.sciencedirect.com/science/article/pii/S0304383513002206http://hdl.handle.net/20.500.11754/43973
- ISSN
- 0304-3835
- DOI
- 10.1016/j.canlet.2013.02.057
- Appears in Collections:
- COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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