Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 최동호 | - |
dc.date.accessioned | 2018-03-09T02:19:51Z | - |
dc.date.available | 2018-03-09T02:19:51Z | - |
dc.date.issued | 2013-07 | - |
dc.identifier.citation | Cancer Letters, Vol.335, No.2 [2013], p372-379 | en_US |
dc.identifier.issn | 0304-3835 | - |
dc.identifier.uri | http://www.sciencedirect.com/science/article/pii/S0304383513002206 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/43973 | - |
dc.description.abstract | Aberrant promoter methylation of tumor suppressor genes including retinoic acid receptor-beta(2) (RAR-beta(2)) is frequently detected in hepatitis C virus (HCV)-associated hepatocellular carcinoma; however, the mechanism and its significance are relatively unknown. Here, we showed that HCV Core induced promoter hypermethylation of RAR-beta(2) to inhibit its expression via up-regulation of DNA methyltransferases 1 and 3b. Under the condition, all-trans retinoic acid (ATRA) failed to activate p16 expression and thus could not inactivate the Rb-E2F pathway. Accordingly, Core-expressing cells exhibited resistance to ATRA-induced growth inhibition. Taken together, HCV Core antagonizes ATRA, a natural anti-cancer compound, to stimulate cell growth via epigenetic down-regulation of RAR-beta(2). (C) 2013 Elsevier Ireland Ltd. All rights reserved. | en_US |
dc.description.sponsorship | This work was supported by the National Research Foundation of Korea (NRF) Grant funded by the Korea government (MEST) (No.2012R1A1B3002555). | en_US |
dc.language.iso | en | en_US |
dc.publisher | ELSEVIER IRELAND LTD, ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND | en_US |
dc.subject | All-trans retinoic acid | en_US |
dc.subject | DNA methylation | en_US |
dc.subject | HCV Core | en_US |
dc.subject | Retinoic acid receptor-beta(2) | en_US |
dc.subject | p16 | en_US |
dc.subject | TUMOR-SUPPRESSOR GENES | en_US |
dc.subject | E-CADHERIN EXPRESSION | en_US |
dc.subject | HEPATOCELLULAR-CARCINOMA | en_US |
dc.subject | PROMOTER HYPOMETHYLATION | en_US |
dc.subject | UP-REGULATION | en_US |
dc.subject | CANCER CELLS | en_US |
dc.subject | LUNG-CANCER | en_US |
dc.subject | X PROTEIN | en_US |
dc.subject | BETA | en_US |
dc.subject | DIFFERENTIATION | en_US |
dc.title | Hepatitis C virus Core protein overcomes all-trans retinoic acid-induced cell growth arrest by inhibiting retinoic acid receptor-beta(2) expression via DNA methylation | en_US |
dc.type | Article | en_US |
dc.relation.volume | 335 | - |
dc.identifier.doi | 10.1016/j.canlet.2013.02.057 | - |
dc.relation.page | 372-379 | - |
dc.relation.journal | CANCER LETTERS | - |
dc.contributor.googleauthor | Lee, Hye-Hyeon | - |
dc.contributor.googleauthor | Woo, Young-Ju | - |
dc.contributor.googleauthor | Kim, Soo-Shin | - |
dc.contributor.googleauthor | Kim, Sung-Hyun | - |
dc.contributor.googleauthor | Park, Bum-Joon | - |
dc.contributor.googleauthor | Choi, Dong-Ho | - |
dc.contributor.googleauthor | Jang, Kyung-Lib | - |
dc.relation.code | 2013009313 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | crane87 | - |
dc.identifier.researcherID | 56005259200 | - |
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