A proteoliposome containing apolipoprotein A-I mutant (V156K) enhances rapid tumor regression activity of human origin oncolytic adenovirus in tumor-bearing zebrafish and mice
- Title
- A proteoliposome containing apolipoprotein A-I mutant (V156K) enhances rapid tumor regression activity of human origin oncolytic adenovirus in tumor-bearing zebrafish and mice
- Author
- 윤채옥
- Keywords
- apolipoprotein A-I; oncolytic adenovirus; proteoliposome; reconstituted high-density lipoproteins; zebrafish; HIGH-DENSITY-LIPOPROTEIN; APOA-I; POINT MUTANT; MODEL; CANCER; VIRUS; REGENERATION; ANTIOXIDANT; DELIVERY; VECTORS
- Issue Date
- 2012-08
- Publisher
- SPRINGER
- Citation
- MOLECULES AND CELLS,Vol.34,No.2 [2012],p143-148
- Abstract
- We recently reported that the efficiency of adenoviral gene delivery and virus stability are significantly enhanced when a proteoliposome (PL) containing apolipoprotein (apo) A-I is used in an animal model. In the current study, we tested tumor removal activity of oncolytic adenovirus (Ad) using PL-containing wildtype (WT) or V156K. Oncolytic Ad with or without PL was injected into tumors of zebrafish and nude mice as a Hep3B tumor xenograft model. The V156K-PL-Ad-injected zebrafish, group showed the lowest tumor tissue volume and nucleic acids in the tumor area, whereas injection of Ad alone did not result in adequate removal of tumor activity. Reactive oxygen species (ROS) contents increased two-fold in tumor-bearing ze
- URI
- https://link.springer.com/article/10.1007%2Fs10059-012-2291-4http://hdl.handle.net/20.500.11754/41420
- ISSN
- 1016-8478
- DOI
- 10.1007/s10059-012-2291-4
- Appears in Collections:
- COLLEGE OF ENGINEERING[S](공과대학) > BIOENGINEERING(생명공학과) > Articles
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