Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 윤채옥 | - |
dc.date.accessioned | 2018-03-01T02:39:49Z | - |
dc.date.available | 2018-03-01T02:39:49Z | - |
dc.date.issued | 2012-08 | - |
dc.identifier.citation | MOLECULES AND CELLS,Vol.34,No.2 [2012],p143-148 | en_US |
dc.identifier.issn | 1016-8478 | - |
dc.identifier.uri | https://link.springer.com/article/10.1007%2Fs10059-012-2291-4 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/41420 | - |
dc.description.abstract | We recently reported that the efficiency of adenoviral gene delivery and virus stability are significantly enhanced when a proteoliposome (PL) containing apolipoprotein (apo) A-I is used in an animal model. In the current study, we tested tumor removal activity of oncolytic adenovirus (Ad) using PL-containing wildtype (WT) or V156K. Oncolytic Ad with or without PL was injected into tumors of zebrafish and nude mice as a Hep3B tumor xenograft model. The V156K-PL-Ad-injected zebrafish, group showed the lowest tumor tissue volume and nucleic acids in the tumor area, whereas injection of Ad alone did not result in adequate removal of tumor activity. Reactive oxygen species (ROS) contents increased two-fold in tumor-bearing ze | en_US |
dc.description.sponsorship | This work was supported by the Mid-carrier Researcher Program (2011-0015529), through the National Research Foundation (NRF) of Korea by the Ministry of Education, Science and Technology (MEST) and supported by a grant from the Ministry for Food, Agriculture, Forestry and Fisheries, Republic of Korea to the Animal, Plant and Fisheries Quarantine and Inspection Agency (Project number: Z-AD14-2011-11-01) | en_US |
dc.language.iso | en | en_US |
dc.publisher | SPRINGER | en_US |
dc.subject | apolipoprotein A-I | en_US |
dc.subject | oncolytic adenovirus | en_US |
dc.subject | proteoliposome | en_US |
dc.subject | reconstituted high-density lipoproteins | en_US |
dc.subject | zebrafish | en_US |
dc.subject | HIGH-DENSITY-LIPOPROTEIN | en_US |
dc.subject | APOA-I | en_US |
dc.subject | POINT MUTANT | en_US |
dc.subject | MODEL | en_US |
dc.subject | CANCER | en_US |
dc.subject | VIRUS | en_US |
dc.subject | REGENERATION | en_US |
dc.subject | ANTIOXIDANT | en_US |
dc.subject | DELIVERY | en_US |
dc.subject | VECTORS | en_US |
dc.title | A proteoliposome containing apolipoprotein A-I mutant (V156K) enhances rapid tumor regression activity of human origin oncolytic adenovirus in tumor-bearing zebrafish and mice | en_US |
dc.type | Article | en_US |
dc.relation.no | 2 | - |
dc.relation.volume | 34 | - |
dc.identifier.doi | 10.1007/s10059-012-2291-4 | - |
dc.relation.page | 143-148 | - |
dc.relation.journal | MOLECULES AND CELLS | - |
dc.contributor.googleauthor | Seo, Juyi | - |
dc.contributor.googleauthor | Yun, Chae-Ok | - |
dc.contributor.googleauthor | Kwon, Oh-Joon | - |
dc.contributor.googleauthor | Choi, Eun-Jin | - |
dc.contributor.googleauthor | Song, Jae-Young | - |
dc.contributor.googleauthor | Choi, Inho | - |
dc.relation.code | 2012206841 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF ENGINEERING[S] | - |
dc.sector.department | DEPARTMENT OF BIOENGINEERING | - |
dc.identifier.pid | chaeok | - |
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