Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 안주홍 | - |
dc.date.accessioned | 2018-02-28T04:37:54Z | - |
dc.date.available | 2018-02-28T04:37:54Z | - |
dc.date.issued | 2011-05 | - |
dc.identifier.citation | FEBS Letters 6 May 2011, 585(9),1310-1316 | en_US |
dc.identifier.issn | 0014-5793 | - |
dc.identifier.uri | http://onlinelibrary.wiley.com/doi/10.1016/j.febslet.2011.03.062/abstract | - |
dc.description.abstract | Dicarbonyl/L-xylulose reductase (DCXR) converts L-xylulose into xylitol, and reduces variousa-dicar-bonyl compounds, thus performing a dual role in carbohydrate metabolism and detoxi?cation. Inthis study, we identi?ed DHS-21 as the only DCXR ortholog in Caenorhabditis elegans. The dhs-21gene is expressed in various tissues including the intestine, gonadal sheath cells, uterine seam (utse)cells, the spermathecal-uterus (sp-ut) valve and on the plasma membrane of spermatids. Recombi-nant DHS-21 was shown to convertL-xylulose to xylitol using NADPH as a cofactor. Dhs-21 mutants of C. elegans show defects in longevity, reproduction and egg-laying. Knock-down of daf-16 and elt-2 transcription factors affected dhs-21 expression. These results suggest that DHS-21 isa bona ?de DCXR of C. elegans, essential for normal life span and reproduction. | en_US |
dc.description.sponsorship | We gratefully acknowledge the Caenorhabditis Genetic Centerfor nematode strains, A. Fire for vectors, Yuji Kohara for yk clonesand Akira Hara for the rat DXCR cDNA. We also thank AndrewSingson and Christopher Rongo for sharing their research facilities.This study was supported by a fellowship from the Vietnamesegovernment (11/2006/QD-TTg and 1893/QD-BNN-TCCB; L.T.S.),Women Scientists Program (No. 2010-0006121; S-.K.Lee), andWorld Class University Program (No. R33-2008-000-10026-0;J. Ahnn) from the National Research Foundation of Korea. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsevier Science B.V., Amsterdam | en_US |
dc.subject | dhs-21 | en_US |
dc.subject | L-Xylulose reductase | en_US |
dc.subject | Longevity | en_US |
dc.subject | Egg-laying | en_US |
dc.subject | Gene expression | en_US |
dc.title | DHS-21, a dicarbonyl/L-xylulose reductase (DCXR) ortholog, regulates longevity and reproduction in Caenorhabditis elegans | en_US |
dc.title.alternative | L-xylulose reductase (DCXR) ortholog, regulates longevity and reproduction in Caenorhabditis elegans | en_US |
dc.type | Article | en_US |
dc.relation.no | 9 | - |
dc.relation.volume | 585 | - |
dc.identifier.doi | 10.1016/j.febslet.2011.03.062 | - |
dc.relation.page | 1310-1316 | - |
dc.relation.journal | FEBS LETTERS | - |
dc.contributor.googleauthor | Son, LT | - |
dc.contributor.googleauthor | Choi, T.-W | - |
dc.contributor.googleauthor | Lee, S.-K | - |
dc.contributor.googleauthor | Ahnn, J | - |
dc.contributor.googleauthor | Ko, K.-M | - |
dc.contributor.googleauthor | Song, H.-O | - |
dc.contributor.googleauthor | Cho, J.H | - |
dc.contributor.googleauthor | Singaravelu, G | - |
dc.contributor.googleauthor | Chatterjee, I | - |
dc.contributor.googleauthor | Yu, J.-R | - |
dc.contributor.googleauthor | Park, B.-J | - |
dc.relation.code | 2011203177 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF NATURAL SCIENCES[S] | - |
dc.sector.department | DEPARTMENT OF LIFE SCIENCE | - |
dc.identifier.pid | joohong | - |
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