Expression of activated HER2 in human testes
- Title
- Expression of activated HER2 in human testes
- Author
- 계명찬
- Keywords
- Germ cells; HER2; human; soma; testis; tyrosine phosphorylated
- Issue Date
- 2011-05
- Publisher
- ELSEVIER SCIENCE INC, 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
- Citation
- FERTILITY AND STERILITY,95(8),2725-2728
- Abstract
- The her2 messenger RNA (mRNA) was the most abundant among the erb type-1 tyrosine kinase receptors mRNA in human testis and was statistically significantly decreased in impaired spermatogenesis. Testicular HER2 was tyrosine phosphorylated and strongly expressed in spermatogonia, early spermatocytes, elongating/elongated spermatids, Sertoli cells, Leydig cells, and peritubular cells, suggesting that activated HER2 participates in mitosis and meiotic entry of germ cells, spermiogenesis, and steroidogenesis via mediating the epidermal growth factor-growth factor signaling. (Fertil Steril (R) 2011;95:2725-8. (C)2011 by American Society for Reproductive Medicine.)
- URI
- http://www.fertstert.org/article/S0015-0282(11)00656-X/fulltext
- ISSN
- 0015-0282
- DOI
- 10.1016/j.fertnstert.2011.04.043
- Appears in Collections:
- COLLEGE OF NATURAL SCIENCES[S](자연과학대학) > LIFE SCIENCE(생명과학과) > Articles
- Files in This Item:
There are no files associated with this item.
- Export
- RIS (EndNote)
- XLS (Excel)
- XML