Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김선일 | - |
dc.date.accessioned | 2018-02-23T03:03:19Z | - |
dc.date.available | 2018-02-23T03:03:19Z | - |
dc.date.issued | 2011-05 | - |
dc.identifier.citation | NEUROIMAGE , 56, 1, 174-184 | en_US |
dc.identifier.issn | 1053-8119 | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S1053811911001017 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/40318 | - |
dc.description.abstract | Recent quantitative analyses of the corpus callosum (CC) have tried to assess the interhemispheric connectivity. Based on histological results showing an expansion of callosal extent at the midsagittal plane, without fiber density alterations, callosal extent was interpreted as an index of interhemispheric connectivity. The microstructural properties of the CC have also been investigated extensively using diffusion tensor imaging, to assess interhemispheric connectivity. The relationships between axonal density and callosal extent need to be investigated to understand how these parameters reflect interhemispheric connectivity. We used a semi-automated CC segmentation scheme in T1-weighted magnetic resonance image and fractional anisotropy (FA) image, respectively. The parameterization method of the segmented CC was applied to 47 right-handed healthy adult subjects. The callosal extent and microstructural properties were measured using the callosal thickness and diffusion indices (FA, mean diffusivity, and axial and radial diffusivity), respectively. Our results revealed a correlation between callosal thickness and FA on the posterior body and isthmus of the CC, which suggests that these regions are more sensitive to fiber alterations than other regions. Based on this result, we suggest that both the extent of the CC and its microstructural properties should be considered together in the estimation of interhemispheric connectivity in healthy adult populations. | en_US |
dc.description.sponsorship | This work was supported by the Korea Science and Engineering Foundation (KOSEF) NRL program grant funded by the Korean Government (MEST) (R0A-2007-000-20068-0) and a grant from the Korea Health 21 R and D Project, Ministry of Health and Welfare, Republic of Korea (A050079); and the Samsung Medical Center Clinical Research Development Program grant, #CRL-108011. | en_US |
dc.language.iso | en | en_US |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE, 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA | en_US |
dc.subject | Interhemispheric connectivity | en_US |
dc.subject | Corpus callosum | en_US |
dc.subject | Diffusion tensor imaging | en_US |
dc.subject | Callosal extent | en_US |
dc.subject | Axon density | en_US |
dc.title | The relationships between extent and microstructural properties of the midsagittal corpus callosum in human brain | en_US |
dc.type | Article | en_US |
dc.relation.no | 1 | - |
dc.relation.volume | 56 | - |
dc.identifier.doi | 10.1016/j.neuroimage.2011.01.065 | - |
dc.relation.page | 174-184 | - |
dc.relation.journal | NEUROIMAGE | - |
dc.contributor.googleauthor | Park, Jun-Sung | - |
dc.contributor.googleauthor | Yoon, Uicheul | - |
dc.contributor.googleauthor | Kwak, Ki-Chang | - |
dc.contributor.googleauthor | Seo, Sang Won | - |
dc.contributor.googleauthor | Kim, Sun I. | - |
dc.contributor.googleauthor | Na, Duk L. | - |
dc.contributor.googleauthor | Lee, Jong-Min | - |
dc.relation.code | 2011207004 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF ENGINEERING[S] | - |
dc.sector.department | DIVISION OF ELECTRICAL AND BIOMEDICAL ENGINEERING | - |
dc.identifier.pid | sunkim | - |
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