Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 신인철 | - |
dc.date.accessioned | 2018-02-22T08:51:07Z | - |
dc.date.available | 2018-02-22T08:51:07Z | - |
dc.date.issued | 2011-10 | - |
dc.identifier.citation | CARCINOGENESIS, 32, 10, 1474-1483 | en_US |
dc.identifier.issn | 0143-3334 | - |
dc.identifier.uri | https://academic.oup.com/carcin/article/32/10/1474/2463725 | - |
dc.description.abstract | Cluster of differentiation 24 (CD24) is a small glycosylphosphatidylinositol-linked cell surface molecule that is expressed in a variety of human carcinomas, including breast cancer. To determine the role of CD24 in breast cancer cells, we expressed CD24 in CD24-negative/low and cluster of differentiation 44 (CD44)-positive MDA-MB-231 metastatic breast cancer cells. Forced expression of CD24 resulted in a decrease in c-Raf/mitogen-activated protein/extracellular signal-regulated kinase kinase (MEK)/mitogen-activated protein kinase signaling and reduced cell proliferation. Apoptosis induced by DNA damage was greatly enhanced in MDA-MB-231 CD24 cells as compared with MDA-MB-231 vec cells. CD24 expression efficiently attenuated DNA damage-induced nuclear factor-kappaB (NF-kappa B) signaling in MDA-MB-231 cells. However, in CD24-positive and CD44-negative/low MCF-7 cells, knockdown of CD24 did not significantly affect DNA damage-induced apoptosis nor NF-kappa B signaling. Silencing of CD24 in CD24/CD44-double-positive MDA-MB-468 cells partially rescued DNA damage-induced apoptosis. Transient transfection studies with 293T cells also revealed that CD24 attenuated cell viability and NF-kappa B signaling only when CD44 was cotransfected. These data indicate that CD24 expression potentiated DNA-induced apoptosis by suppressing antiapoptotic NF-kappa B signaling in CD44-expressing cells. | en_US |
dc.language.iso | en | en_US |
dc.publisher | OXFORD UNIV PRESS, GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND | en_US |
dc.subject | apoptosis | en_US |
dc.subject | doxorubicin | en_US |
dc.subject | signal transduction | en_US |
dc.subject | cell proliferation | en_US |
dc.subject | cd44 antigens | en_US |
dc.subject | dna | en_US |
dc.subject | phosphotransferases | en_US |
dc.subject | transfection | en_US |
dc.subject | homing-associated cell adhesion molecule | en_US |
dc.subject | breast cancer cell | en_US |
dc.subject | attenuation | en_US |
dc.subject | molecule | en_US |
dc.subject | mcf-7 cells | en_US |
dc.title | CD24 enhances DNA damage-induced apoptosis by modulating NF-kappa B signaling in CD44-expressing breast cancer cells | en_US |
dc.type | Article | en_US |
dc.relation.no | 10 | - |
dc.relation.volume | 32 | - |
dc.identifier.doi | 10.1093/carcin/bgr173 | - |
dc.relation.page | 1474-1483 | - |
dc.relation.journal | CARCINOGENESIS | - |
dc.contributor.googleauthor | Ju, Ji-hyun | - |
dc.contributor.googleauthor | Jang, Kibeom | - |
dc.contributor.googleauthor | Lee, Kyung-min | - |
dc.contributor.googleauthor | Kim, Minsoon | - |
dc.contributor.googleauthor | Kim, Jongbin | - |
dc.contributor.googleauthor | Yi, Jae Youn | - |
dc.contributor.googleauthor | Noh, Dong-Young | - |
dc.contributor.googleauthor | Shin, Incheol | - |
dc.relation.code | 2011201698 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF NATURAL SCIENCES[S] | - |
dc.sector.department | DEPARTMENT OF LIFE SCIENCE | - |
dc.identifier.pid | incheol | - |
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