Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 신경훈 | - |
dc.date.accessioned | 2018-02-22T02:37:42Z | - |
dc.date.available | 2018-02-22T02:37:43Z | - |
dc.date.issued | 2015-02 | - |
dc.identifier.citation | CHEMOSPHERE, v. 120, Page. 398-406 | en_US |
dc.identifier.issn | 0045-6535 | - |
dc.identifier.issn | 1879-1298 | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0045653514010042?via%3Dihub | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/39381 | - |
dc.description.abstract | The aryl hydrocarbon receptor (AhR) and aryl hydrocarbon nuclear translocator (ARNT) genes from the copepod Tigriopus japonicus (Tj) were cloned to examine their potential functions in the invertebrate putative AhR-CYP signaling pathway. The amino acid sequences encoded by the Tj-AhR and Tj-ARNT genes showed high similarity to homologs of Daphnia and Drosophila, ranging from 68% and 70% similarity for the AhR genes to 56% for the ARNT genes. To determine whether Tj-AhR and Tj-ARNT are modulated by environmental pollutants, transcriptional expression of Tj-AhR and Tj-ARNT was analyzed in response to exposure to five concentrations of polychlorinated biphenyl (PCB 126) (control, 10, 50, 100, 500 mu g L-1), benzo[a]pyrene (B[a]P) (control, 5, 10, 50, 100 mu g L-1), and tributyltin (TBT) (control, 1, 5, 10, 20 mu g L-1) 24 h after exposure. A time-course experiment (0, 3, 6, 12, 24 h) was performed to analyze mRNA expression patterns after exposure to PCB, B[a]P, and TBT. T. japonicus exhibited dose-dependent and time-dependent upregulation of Tj-AhR and Tj-ARNT in response to pollutant exposure, and the degree of expression was dependent on the pollutant, suggesting that pollutants such as PCB, B[a]P, and TBT modulate expression of Tj-AhR and Tj-ARNT genes in the putative AhR-CYP signaling pathway. (C) 2014 Elsevier Ltd. All rights reserved. | en_US |
dc.description.sponsorship | We would like to thank two anonymous reviewers for their constructive comments on this manuscript. This work was supported by a grant entitled "Korea-Polar Ocean Development" (Project no. PM13030) funded by the Ministry of Oceans and Fisheries, Korea and was also supported by a grant (2012R1A1A2000970) from the National Research Foundation. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | en_US |
dc.subject | Copepod | en_US |
dc.subject | Tigriopus japonicus | en_US |
dc.subject | AhR | en_US |
dc.subject | ARNT | en_US |
dc.subject | Polychlorinated biphenyl | en_US |
dc.subject | Benzo[a]pyrene | en_US |
dc.subject | IMMUNOPOSITIVE PROTEINS | en_US |
dc.subject | CYTOCHROME-P450 GENES | en_US |
dc.subject | CYP GENES | en_US |
dc.subject | 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN | en_US |
dc.subject | ELEGANS | en_US |
dc.subject | IDENTIFICATION | en_US |
dc.subject | CYTOSKELETAL | en_US |
dc.subject | XENOBIOTICS | en_US |
dc.subject | MECHANISMS | en_US |
dc.subject | DIVERSITY | en_US |
dc.title | Dose- and time-dependent expression of aryl hydrocarbon receptor (AhR) and aryl hydrocarbon receptor nuclear translocator (ARNT) in PCB-, B[a]P-, and TBT-exposed intertidal copepod Tigriopus japonicus | en_US |
dc.type | Article | en_US |
dc.relation.volume | 120 | - |
dc.identifier.doi | 10.1016/j.chemosphere.2014.07.099 | - |
dc.relation.page | 398-406 | - |
dc.relation.journal | CHEMOSPHERE | - |
dc.contributor.googleauthor | Kim, BM | - |
dc.contributor.googleauthor | Rhee, JS | - |
dc.contributor.googleauthor | Hwang, UK | - |
dc.contributor.googleauthor | Seo, JS | - |
dc.contributor.googleauthor | Shin, KH | - |
dc.contributor.googleauthor | Lee, JS | - |
dc.relation.code | 2015003164 | - |
dc.sector.campus | E | - |
dc.sector.daehak | COLLEGE OF SCIENCE AND CONVERGENCE TECHNOLOGY[E] | - |
dc.sector.department | DEPARTMENT OF MARINE SCIENCE AND CONVERGENCE ENGINEERING | - |
dc.identifier.pid | shinkh | - |
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