전신성류마티스질환에서 Anti-streptolysin O 검사의 재평가
- Title
- 전신성류마티스질환에서 Anti-streptolysin O 검사의 재평가
- Other Titles
- Re-evaluation of the Anti-streptolysin O Test for Systemic Rheumatic Diseases
- Author
- 전래희
- Keywords
- Anti-streptolysin O; Group A streptococcal infections; Systemic rheumatic disease
- Issue Date
- 2011-07
- Publisher
- 대한진단검사의학회
- Citation
- Laboratory Medicine Online, 2011, 3(1), P.153-157
- Abstract
- Background: Anti-streptolysin O (ASO) test is usually used to diagnose group A streptococcal infection-related diseases, such as rheumatic fever,reactive arthritis, and various infectious diseases. Despite the recent declining incidence of these diseases, ASO test is still frequently performed as a screening test to diagnose rheumatic diseases. This study re-evaluated the clinical usefulness of ASO test in systemic rheumatic diseases (SRD). Methods: ASO tests was performed in 825 patients between April and October in 2010. ASO levels were compared between SRD and non-SRD groups of patients. The results of ASO, C-reactive protein (CRP), and rheumatoid factor (RF) were compared among 6 subgroups of SRD: rheumatoid arthritis, systemic lupus erythematosus, ankylosing spondylitis, Behcet disease, Sjogren’s syndrome and others. Results: Positive results in ASO test (>200 IU/mL) were observed in 15.3% (126/825) of the patients tested. None of the ASO positive patients was, however, diagnosed with rheumatic fever or reactive arthritis. There were no statistically significant differences in the mean value (P =0.688)or positive rate (P =0.835) of ASO test between SRD and non-SRD groups. Positive rates of ASO test were also not statistically significant different among six subgroups of SRD patients (all P >0.05), whereas those of CRP and RF tests were significantly different. Conclusions: The usefulness of ASO test is very low for diagnosing SRD, although it is frequently carried out as a screening test. We suggest that ASO test must be performed selectively when diseases from group A streptococcal infection are suspected.
- URI
- https://repository.hanyang.ac.kr/handle/20.500.11754/36707https://labmedonline.org/DOIx.php?id=10.3343/lmo.2011.1.3.5
- ISSN
- 2093-6338
- DOI
- 10.3343/lmo.2011.1.3.5
- Appears in Collections:
- COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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