Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 최한곤 | - |
dc.date.accessioned | 2018-02-08T02:08:05Z | - |
dc.date.available | 2018-02-08T02:08:05Z | - |
dc.date.issued | 2015-05 | - |
dc.identifier.citation | ARCHIVES OF PHARMACAL RESEARCH, v. 38, No. 5, Page. 734-741 | en_US |
dc.identifier.issn | 0253-6269 | - |
dc.identifier.issn | 1976-3786 | - |
dc.identifier.uri | https://link.springer.com/article/10.1007/s12272-014-0404-7 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/36113 | - |
dc.description.abstract | In the present study, we developed the novel 17-allyamino-17-demethoxygeldanamycin (17-AAG)-loaded poly(lactic acid-co-glycolic acid) (PLGA) nanoparticles (NPs) using the combination of sodium lauryl sulfate and poloxamer 407 as the anionic and non-ionic surfactant for stabilization. The PLGA NPs were prepared by emulsification/solvent evaporation method. Both the drug/polymer ratio and phase ratio were 1:10 (w/w). The optimized formulation of 17-AAG-loaded PLGA NPs had a particle size and polydispersity index of 151.6 +/- 2.0 and 0.152 +/- 0.010 nm, respectively, which was further supported by TEM image. The encapsulation efficiency and drug loading capacity were 69.9 and 7.0 %, respectively. In vitro release study showed sustained release. When in vitro release data were fitted to Korsmeyer-Peppas model, the n value was 0.468, which suggested that the drug was released by anomalous or non-Fickian diffusion. In addition, 17-AAG-loaded PLGA NPs in 72 h, displayed approximately 60 % cell viability reduction at 10 mu g/ml 17-AAG concentration, in MCF-7 cell lines, indicating sustained release from NPs. Therefore, our results demonstrated that incorporation of 17-AAG into PLGA NPs could provide a novel effective nanocarrier for the treatment of cancer. | en_US |
dc.description.sponsorship | This research was supported by the Yeungnam University research grants in 2013. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | PHARMACEUTICAL SOC KOREA | en_US |
dc.subject | 17-Allyamino-17-demethoxygeldanamycin | en_US |
dc.subject | Polylactic acid-co-glycolic acid | en_US |
dc.subject | Nanoparticles | en_US |
dc.subject | Sodium lauryl sulfate | en_US |
dc.subject | Poloxamer | en_US |
dc.subject | LOADED PLGA NANOPARTICLES | en_US |
dc.subject | BEHAVIOR IN-VITRO | en_US |
dc.subject | PHASE-II TRIAL | en_US |
dc.subject | PROSTATE-CANCER | en_US |
dc.subject | DRUG-DELIVERY | en_US |
dc.subject | SOLID TUMORS | en_US |
dc.subject | RELEASE | en_US |
dc.subject | FORMULATION | en_US |
dc.subject | DESIGN | en_US |
dc.subject | 17-ALLYLAMINO-17-DEMETHOXYGELDANAMYCIN | en_US |
dc.title | Preparation and evaluation of 17-allyamino-17-demethoxygeldanamycin (17-AAG)-loaded poly(lactic acid-co-glycolic acid) nanoparticles | en_US |
dc.type | Article | en_US |
dc.relation.no | 5 | - |
dc.relation.volume | 38 | - |
dc.identifier.doi | 10.1007/s12272-014-0404-7 | - |
dc.relation.page | 734-741 | - |
dc.relation.journal | ARCHIVES OF PHARMACAL RESEARCH | - |
dc.contributor.googleauthor | Pradhan, R | - |
dc.contributor.googleauthor | Poudel, BK | - |
dc.contributor.googleauthor | Choi, JY | - |
dc.contributor.googleauthor | Choi, IS | - |
dc.contributor.googleauthor | Shin, BS | - |
dc.contributor.googleauthor | Choi, HG | - |
dc.contributor.googleauthor | Yong, CS | - |
dc.contributor.googleauthor | Kim, JO | - |
dc.relation.code | 2015009399 | - |
dc.sector.campus | E | - |
dc.sector.daehak | COLLEGE OF PHARMACY[E] | - |
dc.sector.department | DEPARTMENT OF PHARMACY | - |
dc.identifier.pid | hangon | - |
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