Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 진언선 | - |
dc.date.accessioned | 2018-02-02T05:55:09Z | - |
dc.date.available | 2018-02-02T05:55:09Z | - |
dc.date.issued | 2011-02 | - |
dc.identifier.citation | INTERNATIONAL JOURNAL OF PHARMACEUTICS, v. 405, NO 1-2, Page. 137-141 | en_US |
dc.identifier.issn | 0378-5173 | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0378517310009282?via%3Dihub | - |
dc.description.abstract | The present study aimed to design the liposomal delivery system for TD53, a novel algicial drug in order to improve the delivery properties of TD53 and evaluate its algicidal effects as well as selectivity against harmful and non-harmful algae. Liposomes of TD53 were prepared with 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) by a lyophilization, resulting in relatively small size vesicles (234 +/- 38 nm) and narrow size distribution (PI = 0.130 +/- 0.027). The drug leakage from the liposome was negligible in the F/2 media (<2% during 96 h incubation). Subsequently algicidal activity of liposomal TD53 against harmful and nonharmful algae was evaluated at various concentrations. The IC(50) values of TD53 in liposome against harmful algae such as Chattonella marina, Heterosigma akashiwo and Cocholodinium polykrikoides were 2.675, 2.029, and 0.480 mu M, respectively, and were reduced by approximately 50% compared to those obtained from non-liposomal TD53. In contrast, the algicidal effect of liposomal TD53 was insignificant against non-harmful algae including Navicula pelliculosa, Nannochloropsis oculata and Phaeodactylum EPV. Those results suggested that liposomal delivery systems might be effective to enhance the efficacy of TD53 while maintaining the selectivity to harmful algal species. | en_US |
dc.description.sponsorship | This research was supported by the Pioneer Research CenterProgram through the National Research Program of Korea fundedby the Ministry of Education, Science and Technology (grant no.M1071118001-08M1118-00110). | en_US |
dc.language.iso | en | en_US |
dc.publisher | ELSEVIER SCIENCE BV | en_US |
dc.subject | Harmful algae | en_US |
dc.subject | Liposome | en_US |
dc.subject | Algicidal activity | en_US |
dc.subject | TD53 | en_US |
dc.subject | Delivery system | en_US |
dc.title | Enhanced efficacy of TD53, a novel algicidal agent, against the harmful algae via the liposomal delivery system | en_US |
dc.type | Article | en_US |
dc.relation.no | 1-2 | - |
dc.relation.volume | 405 | - |
dc.identifier.doi | 10.1016/j.ijpharm.2010.12.008 | - |
dc.relation.page | 137-141 | - |
dc.relation.journal | INTERNATIONAL JOURNAL OF PHARMACEUTICS | - |
dc.contributor.googleauthor | Han, H.K. | - |
dc.contributor.googleauthor | Kim, Y.M. | - |
dc.contributor.googleauthor | Lim, S.J. | - |
dc.contributor.googleauthor | Hong, S.S. | - |
dc.contributor.googleauthor | Jung, S.G. | - |
dc.contributor.googleauthor | Cho, H. | - |
dc.contributor.googleauthor | Lee, W. | - |
dc.contributor.googleauthor | Jin, E. | - |
dc.relation.code | 2011204294 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF NATURAL SCIENCES[S] | - |
dc.sector.department | DEPARTMENT OF LIFE SCIENCE | - |
dc.identifier.pid | esjin | - |
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