Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이진원 | - |
dc.date.accessioned | 2018-02-01T00:10:14Z | - |
dc.date.available | 2018-02-01T00:10:14Z | - |
dc.date.issued | 2011-02 | - |
dc.identifier.citation | PEPTIDES, v. 32, NO 5, Page. 895-899 | en_US |
dc.identifier.issn | 0196-9781 | - |
dc.identifier.issn | 1873-5169 | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0196978111000799 | - |
dc.description.abstract | Buforin Ilb is a novel cell-penetrating anticancer peptide derived from histone H2A. In this study, we enhanced the cancer targeting specificity of buforin Ilb using a tumor-associated enzyme-controlled activation strategy. Buforin Ilb was fused with an anionic peptide (modified magainin intervening sequence, MMIS), which neutralizes the positive charge of buforin lib and thus renders it inactive, via a matrix metalloproteinases (MMPs)-cleavable linker. The resulting MMIS:buforin Ilb fusion peptide was completely inactive against MMPs-nonproducing cells. However, when the fusion peptide was administrated to MMPs-producing cancer cells, it regained the killing activity by releasing free buforin Ilb through MMPs-mediated cleavage. Moreover, the activity of the fusion peptide toward MMPs-producing cancer cells was significantly decreased when the cells were pretreated with a MMP inhibitor. Taken together, these data indicate that the cancer targeting specificity of MMIS:buforin Ilb is enhanced compared to the parent peptide by reactivation at the specialized areas where MMPs are pathologically produced. | en_US |
dc.language.iso | en | en_US |
dc.publisher | ELSEVIER SCIENCE INC | en_US |
dc.subject | Buforin lib | en_US |
dc.subject | Anticancer peptide | en_US |
dc.subject | Antimicrobial peptide | en_US |
dc.subject | Fusion peptide | en_US |
dc.subject | Matrix metalloproteinase | en_US |
dc.title | Enhancement of the cancer targeting specificity of buforin lib by fusion with an anionic peptide via a matrix metalloproteinases-cleavable linker | en_US |
dc.type | Article | en_US |
dc.relation.no | 5 | - |
dc.relation.volume | 32 | - |
dc.identifier.doi | 10.1016/j.peptides.2011.02.010 | - |
dc.relation.page | 895-899 | - |
dc.relation.journal | PEPTIDES | - |
dc.contributor.googleauthor | Jang, Ju Hye | - |
dc.contributor.googleauthor | Kim, Min Young | - |
dc.contributor.googleauthor | Lee, Jin-Won | - |
dc.contributor.googleauthor | Kim, Sun Chang | - |
dc.contributor.googleauthor | Cho, Ju Hyun | - |
dc.relation.code | 2011207485 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF NATURAL SCIENCES[S] | - |
dc.sector.department | DEPARTMENT OF LIFE SCIENCE | - |
dc.identifier.pid | jwl | - |
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