Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이종민 | - |
dc.date.accessioned | 2017-12-11T06:49:43Z | - |
dc.date.available | 2017-12-11T06:49:43Z | - |
dc.date.issued | 2016-02 | - |
dc.identifier.citation | EUROPEAN NEUROLOGY, v. 75, NO 1-2, Page. 96-103 | en_US |
dc.identifier.issn | 0014-3022 | - |
dc.identifier.issn | 1421-9913 | - |
dc.identifier.uri | https://www.karger.com/Article/FullText/443206 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/34060 | - |
dc.description.abstract | We investigated white matter integrity utilizing diffusion tensor imaging in patients with idiopathic normal-pressure hydrocephalus (INPH) who had a positive response to the cerebrospinal fluid tap test and in age- and gender-matched Alzheimer's disease (AD) patients. We enrolled 28 patients with INPH, 28 patients with AD and 20 healthy controls. Tract-based spatial statistics demonstrated that INPH patients had lower fractional anisotropy (FA) in the anterior corona radiate (bilateral), corpus callosum, superior longitudinal fasciculus (bilateral), posterior thalamic radiation (bilateral), external capsule (bilateral) and middle cerebellar peduncle in comparison with the AD and control groups. Volume-of-interest analysis revealed that INPH patients, when compared to the AD and control groups, showed higher mean diffusivity in the anterior corona radiate (bilateral), corpus callosum, superior longitudinal fasciculus (bilateral), posterior thalamic radiation (left), external capsule (bilateral) and middle cerebellar peduncle. And gait dysfunction was significantly correlated with decreased FA in the splenium of the corpus callosum and right external capsule in INPH patients. Our findings may suggest a possibility for considering microstructural changes in white matter integrity in elderly patients as potential imaging markers for differentiation between INPH and AD and may help us understand the potential pathophysiology of gait disturbances associated with INPH. (C) 2016 S. Karger AG, Basel | en_US |
dc.description.sponsorship | The authors would like to thank Wade Martin of Medical Research International for his critical English revision. This research was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute, funded by the Ministry of Health and Welfare, Republic of Korea (HI14C3331) and the Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Science, ICT and Future Planning (2014R1A1A1005536). | en_US |
dc.language.iso | en | en_US |
dc.publisher | KARGER | en_US |
dc.subject | Diffusion tensor imaging | en_US |
dc.subject | Normal-pressure hydrocephalus | en_US |
dc.subject | Alzheimer's disease | en_US |
dc.title | Abnormal White Matter Integrity in Elderly Patients with Idiopathic Normal-Pressure Hydrocephalus: A Tract-Based Spatial Statistics Study | en_US |
dc.type | Article | en_US |
dc.relation.no | 1-2 | - |
dc.relation.volume | 75 | - |
dc.identifier.doi | 10.1159/000443206 | - |
dc.relation.page | 96-103 | - |
dc.relation.journal | EUROPEAN NEUROLOGY | - |
dc.contributor.googleauthor | Kang, Kyunghun | - |
dc.contributor.googleauthor | Choi, Woohyuk | - |
dc.contributor.googleauthor | Yoon, Uicheul | - |
dc.contributor.googleauthor | Lee, Jong-Min | - |
dc.contributor.googleauthor | Lee, Ho-Won | - |
dc.relation.code | 2016001629 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF ENGINEERING[S] | - |
dc.sector.department | DIVISION OF ELECTRICAL AND BIOMEDICAL ENGINEERING | - |
dc.identifier.pid | ljm | - |
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