Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 이종민 | - |
dc.date.accessioned | 2017-12-11T06:46:38Z | - |
dc.date.available | 2017-12-11T06:46:38Z | - |
dc.date.issued | 2016-02 | - |
dc.identifier.citation | NEUROLOGY, v. 86, NO 6, Page. 527-534 | en_US |
dc.identifier.issn | 0028-3878 | - |
dc.identifier.issn | 1526-632X | - |
dc.identifier.uri | http://n.neurology.org/content/86/6/527 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/34059 | - |
dc.description.abstract | Objective:To evaluate the differences between early-onset subcortical vascular cognitive impairment (EO-SVCI) and late-onset subcortical vascular cognitive impairment (LO-SVCI) with regard to pathologic burden, structural changes, and cognitive function.Methods:We prospectively recruited 142 patients from a single referral center. Patients were divided into EO-SVCI (n = 30, age at onset <65 years) and LO-SVCI (n = 112, age at onset 65 years) groups. All patients underwent neuropsychological tests, 3T brain MRI, and [C-11] Pittsburgh compound B (PiB)-PET. We compared pathologic burden such as small vessel disease and amyloid burden; structural changes such as structural network, cortical thickness, and hippocampal volume; and cognitive function between EO-SVCI and LO-SVCI.Results:EO-SVCI patients had more lacunes, while LO-SVCI patients had higher PiB standardized uptake value ratios. EO-SVCI patients exhibited more severe structural network disruptions in the frontal area, while LO-SVCI patients exhibited more severe cortical and hippocampal atrophy. Although disease severity did not differ between the 2 groups, frontal-executive dysfunction was more severe in EO-SVCI patients.Conclusions:EO-SVCI patients showed more vascular related factors, while LO-SVCI patients exhibited more Alzheimer disease-related characteristics. The greater number of lacunes in EO-SVCI might account for the more severe frontal network disruption and frontal-executive dysfunction, while the greater amyloid burden in LO-SVCI might account for the more severe cortical and hippocampal atrophy. Our findings suggest that the age at onset is a crucial factor that determines distinct features in SVCI patients, such as pathologic burden, structural changes, and cognitive function. | en_US |
dc.description.sponsorship | This study was supported by the Basic Research Program of the National Research Foundation (NRF) of South Korea and was funded by the Ministry of Education (NRF-2013R1A1A2065365), the Korean Healthcare Technology R&D Project, the Ministry for Health and Welfare Affairs (HIC120713), a Korean Science and Engineering Foundation (KOSEF) NRL program grant funded by the Korean government (MEST; 20110028333), a Samsung Medical Center Clinical Research Development Program grant (CRL108011 & CRS 110-14-1), the Korea Ministry of Environment (MOE) Environmental Health Action Program (2014001360002), National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP) (NRF-2015R1C1A2A01053281), the Original Technology Research Program for Brain Science through the National Research Foundation of Korea (NRF) funded by the Korean government (MSIP) (No. 2014M3C7A1064752), and a grant of the Korean Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea (HI14C2746). | en_US |
dc.language.iso | en | en_US |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | en_US |
dc.subject | WHITE-MATTER LESIONS | en_US |
dc.subject | SMALL VESSEL DISEASE | en_US |
dc.subject | FRONTOTEMPORAL DEMENTIA | en_US |
dc.subject | INCREASED PREVALENCE | en_US |
dc.subject | GLUCOSE-METABOLISM | en_US |
dc.subject | ALZHEIMERS-DISEASE | en_US |
dc.subject | AMYLOID BURDEN | en_US |
dc.subject | COMPOUND B | en_US |
dc.subject | BRAIN | en_US |
dc.subject | BETA | en_US |
dc.title | Early- vs late-onset subcortical vascular cognitive impairment | en_US |
dc.type | Article | en_US |
dc.relation.no | 6 | - |
dc.relation.volume | 86 | - |
dc.identifier.doi | 10.1212/WNL.0000000000002357 | - |
dc.relation.page | 527-534 | - |
dc.relation.journal | NEUROLOGY | - |
dc.contributor.googleauthor | Jang, Young Kyoung | - |
dc.contributor.googleauthor | Kwon, Hunki | - |
dc.contributor.googleauthor | Kim, Yeo Jin | - |
dc.contributor.googleauthor | Jung, Na Yeon | - |
dc.contributor.googleauthor | Lee, Jin San | - |
dc.contributor.googleauthor | Lee, Juyoun | - |
dc.contributor.googleauthor | Chin, Juhee | - |
dc.contributor.googleauthor | Im, Kiho | - |
dc.contributor.googleauthor | Jeon, Seun | - |
dc.contributor.googleauthor | Lee, Jong Min | - |
dc.relation.code | 2016001633 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF ENGINEERING[S] | - |
dc.sector.department | DIVISION OF ELECTRICAL AND BIOMEDICAL ENGINEERING | - |
dc.identifier.pid | ljm | - |
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