Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이종민 | - |
dc.date.accessioned | 2017-12-11T06:24:49Z | - |
dc.date.available | 2017-12-11T06:24:49Z | - |
dc.date.issued | 2016-02 | - |
dc.identifier.citation | AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY, v. 24, NO 2, Page. 144-153 | en_US |
dc.identifier.issn | 1064-7481 | - |
dc.identifier.issn | 1545-7214 | - |
dc.identifier.uri | http://www.sciencedirect.com/science/article/pii/S1064748115001906?via%3Dihub | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/34058 | - |
dc.description.abstract | Objectives: The present study investigated the characteristics of amnestic mild cognitive impairment (aMCI) in subjects with low brain amyloid-beta (Ab) burden. Furthermore, the relationships between amyloid-independent cognitive decline and serum lipid profiles, particularly apolipoprotein A1 (APOA1), were evaluated. Design: Cross-sectional and longitudinal follow-up study. Setting: University hospital dementia clinic. Participants: 28 aMCI and 35 cognitive normal (CN) elderly. Measurements: The study measures included baseline assessments of the subjects' clinical characteristics, lipid profiles, and magnetic resonance imaging and C-11-labelled Pittsburgh Compound B (PiB) positron emission tomography scans. Based on PiB retention at baseline, the aMCI subjects were divided into low A beta (aMCI-) and high A beta (aMCI+) subgroups. All aMCI subjects were followed up over a 1-year period. Results: The aMCI- group had a longer duration of illness than did the aMCI \ group. None of the aMCI subjects were diagnosed with Alzheimer disease (AD) dementia during the 1-year follow-up period, whereas 26.7% of aMCI+ subjects developed AD dementia. The aMCI- group also exhibited lower serum APOA1 levels compared with both the aMCI+ and CN groups. Additionally, lower serum APOA1 levels were associated with cognitive decline and brain atrophy independent of A beta deposition and vascular burden. Conclusions: Patients with aMCI- likely exhibit different clinical and pathophysiological characteristics than patients with aMCI+. Additionally, APOA1 may be an important contributor underlying amyloid-independent neurodegeneration. | en_US |
dc.description.sponsorship | This study was supported by a grant from the Korea Healthcare Technology R & D Project, Ministry of Health, Welfare and Family Affairs, Republic of Korea (grant no. A092145), a grant from the Korean government (MEST; grant no. 2011-0028333), and a grant from the Ministry of Science, ICT, and Future Planning, Republic of Korea (grant no. NRF-2014M3C7A1046042). | en_US |
dc.language.iso | en | en_US |
dc.publisher | ELSEVIER SCIENCE INC | en_US |
dc.subject | Amyloid PET | en_US |
dc.subject | MRI | en_US |
dc.subject | mild cognitive impairment | en_US |
dc.subject | Alzheimer disease | en_US |
dc.subject | apolipoprotein | en_US |
dc.title | Amyloid-Independent Amnestic Mild Cognitive Impairment and Serum Apolipoprotein A1 Levels | en_US |
dc.type | Article | en_US |
dc.relation.no | 2 | - |
dc.relation.volume | 24 | - |
dc.identifier.doi | 10.1016/j.jagp.2015.06.004 | - |
dc.relation.page | 144-153 | - |
dc.relation.journal | AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY | - |
dc.contributor.googleauthor | Choi, Hyo Jung | - |
dc.contributor.googleauthor | Seo, Eun Hyun | - |
dc.contributor.googleauthor | Yi, Dahyun | - |
dc.contributor.googleauthor | Sohn, Bo Kyung | - |
dc.contributor.googleauthor | Choe, Young Min | - |
dc.contributor.googleauthor | Byun, Min Soo | - |
dc.contributor.googleauthor | Lee, Jong Min | - |
dc.contributor.googleauthor | Woo, Jong Inn | - |
dc.contributor.googleauthor | Lee, Dong Young | - |
dc.relation.code | 2016000258 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF ENGINEERING[S] | - |
dc.sector.department | DIVISION OF ELECTRICAL AND BIOMEDICAL ENGINEERING | - |
dc.identifier.pid | ljm | - |
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