366 0

Full metadata record

DC FieldValueLanguage
dc.contributor.author이성온-
dc.date.accessioned2017-12-05T01:22:05Z-
dc.date.available2017-12-05T01:22:05Z-
dc.date.issued2015-06-
dc.identifier.citationFRONTIERS IN PHYSIOLOGY, v. 6, NO MAY, Page. 0-0en_US
dc.identifier.issn1664-042X-
dc.identifier.urihttps://doaj.org/article/3f749eb66cbc44bfb1bb5b24cebb1159?-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/33936-
dc.description.abstractIntravital imaging microscopy (i.e., imaging in live animals at microscopic resolution) has become an indispensable tool for studying the cellular micro-dynamics in cancer, immunology and neurobiology. High spatial and temporal resolution, combined with large penetration depth and multi-reporter visualization capability make fluorescence intravital microscopy compelling for heart imaging. However, tissue motion caused by cardiac contraction and respiration critically limits its use. As a result, in vitro cell preparations or non-contracting explanted heart models are more commonly employed. Unfortunately, these approaches fall short of understanding the more complex host physiology that may be dynamic and occur over longer periods of time. In this review, we report on novel technologies, which have been recently developed by our group and others, aimed at overcoming motion-induced artifacts and capable of providing in vivo subcellular resolution imaging in the beating mouse heart. The methods are based on mechanical stabilization, image processing algorithms, gated/triggered acquisition schemes or a combination of both. We expect that in the immediate future all these methodologies will have considerable applications in expanding our understanding of the cardiac biology, elucidating cardiomyocyte function and interactions within the organism in vivo, and ultimately improving the treatment of cardiac diseases. © 2015 Vinegoni, Lee, Aguirre and Weissleder.en_US
dc.language.isoen_USen_US
dc.publisherFRONTIERS MEDIA SAen_US
dc.titleNew techniques for motion-artifact-free in vivo cardiac microscopyen_US
dc.typeArticleen_US
dc.relation.noMAY-
dc.relation.volume6-
dc.identifier.doi10.3389/fphys.2015.00147-
dc.relation.page0-0-
dc.relation.journalFRONTIERS IN PHYSIOLOGY-
dc.contributor.googleauthorClaudio, Vinegoni-
dc.contributor.googleauthorAaron, Aguirre-
dc.contributor.googleauthorAaron, Aguirre-
dc.contributor.googleauthorRalph, Weissleder-
dc.contributor.googleauthorLee, Sungon-
dc.relation.code2015041909-
dc.sector.campusE-
dc.sector.daehakCOLLEGE OF ENGINEERING SCIENCES[E]-
dc.sector.departmentDIVISION OF ELECTRICAL ENGINEERING-
dc.identifier.pidsungon-
Appears in Collections:
COLLEGE OF ENGINEERING SCIENCES[E](공학대학) > ELECTRICAL ENGINEERING(전자공학부) > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE