Interaction of Wnt5a with Notch1 is Critical for the Pathogenesis of Psoriasis
- Title
- Interaction of Wnt5a with Notch1 is Critical for the Pathogenesis of Psoriasis
- Author
- 김정은
- Keywords
- Notch1; Psoriasis; Wnt5a
- Issue Date
- 2016-02
- Publisher
- KOREAN DERMATOLOGICAL ASSOC
- Citation
- ANNALS OF DERMATOLOGY, v. 28, NO 1, Page. 45-54
- Abstract
- Background: Psoriasis is characterized by uncontrolled hyperproliferation, aberrant differentiation, and dermal infiltration of immune cells. Recent studies have reported that Wnt5a and Notch1 signaling are altered in psoriatic skin lesions. Objective: We aimed to investigate the interaction of Wnt5a with Notch 1 with respect to inflammation-mediated epidermal hyperproliferation in psoriasis. Methods: Expression of Wnt5a and Notch1 signaling-related proteins were examined in psoriatic skin biopsies. Wnt5a was upregulated in human keratinocytes by treating the cells with its recombinant form (rWnt5a). Results: In psoriatic lesions, expression of Wnt5a increased while that of Notch1 decreased when compared to that in non-lesional and normal skin. Treatment with rWnt5a increased the proliferation of keratinocytes and increased their secretion of interleukin (IL)-23, IL-12, and tumor necrosis factor (TNF)-alpha. Further, exposure of keratinocytes to IL-1 alpha, TNF-alpha, transforming growth factor-alpha, and interferon-gamma downregulated Notch1 as well as HES1, which is downstream to Notch1, but increased the Wnt5a levels. The upregulated Wnt5a in keratinocytes downregulated both Notch1 and HES1. Conclusion: Our data suggest that Wnt5a and Notch1 signaling exert counteracting influences on each other and are involved, in part, in the pathomechanism of psoriasis.
- URI
- https://synapse.koreamed.org/DOIx.php?id=10.5021/ad.2016.28.1.45http://hdl.handle.net/20.500.11754/31805
- ISSN
- 1013-9087
- DOI
- 10.5021/ad.2016.28.1.45
- Appears in Collections:
- COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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