Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김정은 | - |
dc.date.accessioned | 2017-11-23T05:33:16Z | - |
dc.date.available | 2017-11-23T05:33:16Z | - |
dc.date.issued | 2016-02 | - |
dc.identifier.citation | ANNALS OF DERMATOLOGY, v. 28, NO 1, Page. 45-54 | en_US |
dc.identifier.issn | 1013-9087 | - |
dc.identifier.uri | https://synapse.koreamed.org/DOIx.php?id=10.5021/ad.2016.28.1.45 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/31805 | - |
dc.description.abstract | Background: Psoriasis is characterized by uncontrolled hyperproliferation, aberrant differentiation, and dermal infiltration of immune cells. Recent studies have reported that Wnt5a and Notch1 signaling are altered in psoriatic skin lesions. Objective: We aimed to investigate the interaction of Wnt5a with Notch 1 with respect to inflammation-mediated epidermal hyperproliferation in psoriasis. Methods: Expression of Wnt5a and Notch1 signaling-related proteins were examined in psoriatic skin biopsies. Wnt5a was upregulated in human keratinocytes by treating the cells with its recombinant form (rWnt5a). Results: In psoriatic lesions, expression of Wnt5a increased while that of Notch1 decreased when compared to that in non-lesional and normal skin. Treatment with rWnt5a increased the proliferation of keratinocytes and increased their secretion of interleukin (IL)-23, IL-12, and tumor necrosis factor (TNF)-alpha. Further, exposure of keratinocytes to IL-1 alpha, TNF-alpha, transforming growth factor-alpha, and interferon-gamma downregulated Notch1 as well as HES1, which is downstream to Notch1, but increased the Wnt5a levels. The upregulated Wnt5a in keratinocytes downregulated both Notch1 and HES1. Conclusion: Our data suggest that Wnt5a and Notch1 signaling exert counteracting influences on each other and are involved, in part, in the pathomechanism of psoriasis. | en_US |
dc.description.sponsorship | This work was supported by the Korean Science Ministry NRF 2011-0009121, Asan Life Science Institute 2011-415; and a grant of Korean Health Technology R&D project, Ministry of Health & Welfare, Republic of Korea (A110564). | en_US |
dc.language.iso | en | en_US |
dc.publisher | KOREAN DERMATOLOGICAL ASSOC | en_US |
dc.subject | Notch1 | en_US |
dc.subject | Psoriasis | en_US |
dc.subject | Wnt5a | en_US |
dc.title | Interaction of Wnt5a with Notch1 is Critical for the Pathogenesis of Psoriasis | en_US |
dc.type | Article | en_US |
dc.relation.no | 1 | - |
dc.relation.volume | 28 | - |
dc.identifier.doi | 10.5021/ad.2016.28.1.45 | - |
dc.relation.page | 45-54 | - |
dc.relation.journal | ANNALS OF DERMATOLOGY | - |
dc.contributor.googleauthor | Kim, Jeong Eun | - |
dc.contributor.googleauthor | Bang, Seung Hyun | - |
dc.contributor.googleauthor | Choi, Jee Ho | - |
dc.contributor.googleauthor | Kim, Chang Deok | - |
dc.contributor.googleauthor | Won, Chong Hyun | - |
dc.contributor.googleauthor | Lee, Mi Woo | - |
dc.contributor.googleauthor | Chang, Sung Eun | - |
dc.relation.code | 2016008933 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | dermakim | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.