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dc.contributor.author김계성-
dc.date.accessioned2017-10-24T00:37:09Z-
dc.date.available2017-10-24T00:37:09Z-
dc.date.issued2015-12-
dc.identifier.citationCELLULAR AND MOLECULAR LIFE SCIENCES, v. 72, NO 24, Page. 4711-4720en_US
dc.identifier.issn1420-682X-
dc.identifier.issn1420-9071-
dc.identifier.urihttps://link.springer.com/article/10.1007%2Fs00018-015-2030-z-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/30208-
dc.description.abstractSpermatogenesis is a complex process through which spermatogonial stem cells undergo mitosis, meiosis, and cell differentiation to generate mature spermatozoa. During this process, male germ cells experience several translational modifications. One of the major post-translational modifications in eukaryotes is the ubiquitination of proteins, which targets proteins for degradation; this enables control of the expression of enzymes and structural proteins during spermatogenesis. It has become apparent that ubiquitination plays a key role in regulating every stage of spermatogenesis starting from gonocytes to differentiated spermatids. It is understood that, where there is ubiquitination, deubiquitination by deubiquitinating enzymes (DUBs) also exists to counterbalance the ubiquitination process in a reversible manner. Normal spermatogenesis is dependent on the balanced actions of ubiquitination and deubiquitination. This review highlights the current knowledge of the role of DUBs and their essential regulatory contribution to spermatogenesis, especially during progression into meiotic phase, acrosome biogenesis, quality sperm production, and apoptosis of germ cells.en_US
dc.description.sponsorshipWe would like to thank all of Suri's laboratory members for their helpful discussions. This study was supported by the Bio & Medical Technology Development Program of the National Research Foundation (NRF) funded by the Korean government (MSIP) (No. 2012M3A9B4028738).en_US
dc.language.isoenen_US
dc.publisherSPRINGER BASEL AGen_US
dc.subjectAcrosomeen_US
dc.subjectGonocytesen_US
dc.subjectMale infertilityen_US
dc.subjectNucleosomeen_US
dc.subjectProteasomeen_US
dc.subjectProtein degradationen_US
dc.subjectSpermiogenesisen_US
dc.subjectUbiquitinen_US
dc.titleThe role of deubiquitinating enzymes in spermatogenesisen_US
dc.typeArticleen_US
dc.relation.no24-
dc.relation.volume72-
dc.identifier.doi10.1007/s00018-015-2030-z-
dc.relation.page4711-4720-
dc.relation.journalCELLULAR AND MOLECULAR LIFE SCIENCES-
dc.contributor.googleauthorSuresh, Bharathi-
dc.contributor.googleauthorLee, Junwon-
dc.contributor.googleauthorHong, Seok-Ho-
dc.contributor.googleauthorKim, Kye-Seong-
dc.contributor.googleauthorRamakrishna, Suresh-
dc.relation.code2015003644-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidks66kim-
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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