TY - JOUR AU - 김계성 DA - 2015/12 PY - 2015 UR - https://link.springer.com/article/10.1007%2Fs00018-015-2030-z UR - http://hdl.handle.net/20.500.11754/30208 AB - Spermatogenesis is a complex process through which spermatogonial stem cells undergo mitosis, meiosis, and cell differentiation to generate mature spermatozoa. During this process, male germ cells experience several translational modifications. One of the major post-translational modifications in eukaryotes is the ubiquitination of proteins, which targets proteins for degradation; this enables control of the expression of enzymes and structural proteins during spermatogenesis. It has become apparent that ubiquitination plays a key role in regulating every stage of spermatogenesis starting from gonocytes to differentiated spermatids. It is understood that, where there is ubiquitination, deubiquitination by deubiquitinating enzymes (DUBs) also exists to counterbalance the ubiquitination process in a reversible manner. Normal spermatogenesis is dependent on the balanced actions of ubiquitination and deubiquitination. This review highlights the current knowledge of the role of DUBs and their essential regulatory contribution to spermatogenesis, especially during progression into meiotic phase, acrosome biogenesis, quality sperm production, and apoptosis of germ cells. PB - SPRINGER BASEL AG KW - Acrosome KW - Gonocytes KW - Male infertility KW - Nucleosome KW - Proteasome KW - Protein degradation KW - Spermiogenesis KW - Ubiquitin TI - The role of deubiquitinating enzymes in spermatogenesis IS - 24 VL - 72 DO - 10.1007/s00018-015-2030-z T2 - CELLULAR AND MOLECULAR LIFE SCIENCES ER -