Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 배상수 | - |
dc.date.accessioned | 2017-10-11T07:25:17Z | - |
dc.date.available | 2017-10-11T07:25:17Z | - |
dc.date.issued | 2015-12 | - |
dc.identifier.citation | BIOINFORMATICS, v. 31, NO 24, Page. 4014-4016 | en_US |
dc.identifier.issn | 1367-4803 | - |
dc.identifier.issn | 1460-2059 | - |
dc.identifier.uri | https://academic.oup.com/bioinformatics/article-lookup/doi/10.1093/bioinformatics/btv537 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/29575 | - |
dc.description.abstract | We present Cas-Designer, a user-friendly program to aid researchers in choosing appropriate target sites in a gene of interest for type II CRISPR/Cas-derived RNA-guided endonucleases, which are now widely used for biomedical research and biotechnology. Cas-Designer rapidly provides the list of all possible guide RNA sequences in a given input DNA sequence and their potential off-target sites including bulge-type sites in a genome of choice. In addition, the program assigns an out-of-frame score to each target site to help users choose appropriate sites for gene knockout. Cas-Designer shows the results in an interactive table and provides user-friendly filter functions. | en_US |
dc.description.sponsorship | The Plant Molecular Breeding Center of Next Generation BioGreen 21 Program (PJ01119201) and the research fund of Hanyang University (HY-2015) to S.B. and Institute for Basic Science (IBS-R021-D1) to J.-S.K. | en_US |
dc.language.iso | en | en_US |
dc.publisher | OXFORD UNIV PRESS | en_US |
dc.subject | RNA-GUIDED ENDONUCLEASES | en_US |
dc.subject | NUCLEASES | en_US |
dc.subject | CRISPR/CAS9 | en_US |
dc.subject | SYSTEMS | en_US |
dc.subject | CELLS | en_US |
dc.subject | DNA | en_US |
dc.title | Cas-Designer: a web-based tool for choice of CRISPR-Cas9 target sites | en_US |
dc.type | Article | en_US |
dc.relation.no | 24 | - |
dc.relation.volume | 31 | - |
dc.identifier.doi | 10.1093/bioinformatics/btv537 | - |
dc.relation.page | 4014-4016 | - |
dc.relation.journal | BIOINFORMATICS | - |
dc.contributor.googleauthor | Park, Jeongbin | - |
dc.contributor.googleauthor | Bae, Sangsu | - |
dc.contributor.googleauthor | Kim, Jin-Soo | - |
dc.relation.code | 2015001233 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF NATURAL SCIENCES[S] | - |
dc.sector.department | DEPARTMENT OF CHEMISTRY | - |
dc.identifier.pid | sangsubae | - |
dc.identifier.researcherID | E-5324-2017 | - |
dc.identifier.orcid | http://orcid.org/0000-0003-3615-8566 | - |
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