Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 안주홍 | - |
dc.date.accessioned | 2017-09-08T00:16:30Z | - |
dc.date.available | 2017-09-08T00:16:30Z | - |
dc.date.issued | 2015-11 | - |
dc.identifier.citation | JOURNAL OF MOLECULAR BIOLOGY, v. 427, NO 22, Page. 3457-3468 | en_US |
dc.identifier.issn | 0022-2836 | - |
dc.identifier.issn | 1089-8638 | - |
dc.identifier.uri | http://linkinghub.elsevier.com/retrieve/pii/S0022283615004192 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/28961 | - |
dc.description.abstract | Regulator of calcineurin (RCAN) is a calcineurin-interacting protein that inhibits calcineurin phosphatase when overexpressed, often upregulated under neuropathological conditions with impaired learning and memory processes, such as Down syndrome or Alzheimer's disease. Thermotactic behavior in the nematode Caenorhabditis elegans is a form of memory in which calcineurin signaling plays a pivotal role in the thermosensation of AFD neurons. In this study, we found that rcan-1 deletion mutants exhibited cryophilic behavior dependent on tax-6, which was rescued by expressing rcan-1 in AFD neurons. Interaction between RCAN-1 and TAX-6 requires the conserved PxIxIT motif of RCAN-1, without which thermotactic behavior could not be fully rescued. In addition, the loss of crh-1/CREB suppressed the thermotaxis phenotypes of rcan-1 and tax-6 mutants, indicating that crh-1 is crucial in thermotaxis memory in these mutants. Taken together, our results suggest that rcan-1 is an inhibitory regulator of tax-6 and that it acts in the formation of thermosensory behavioral memory in C. elegans. (C) 2015 Elsevier Ltd. All rights reserved. | en_US |
dc.description.sponsorship | Several strains were provided by the Caenorhabditis Genetics Center and National BioResource Project (Japan). We sincerely thank Piali Sengupta for comments on this manuscript. This work was supported by the Basic Science Research Program (no. NRF-2013R1A1A3A04006010) through the National Research Foundation of Korea funded by Korean Ministry of Science, ICT, and Future Planning. | en_US |
dc.language.iso | en | en_US |
dc.publisher | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD | en_US |
dc.subject | RCAN | en_US |
dc.subject | calcineurin | en_US |
dc.subject | CREB | en_US |
dc.subject | thermotaxis | en_US |
dc.subject | Caenorhabditis elegans | en_US |
dc.title | Regulator of Calcineurin (RCAN-1) Regulates Thermotaxis Behavior in Caenorhabditis elegans | en_US |
dc.type | Article | en_US |
dc.relation.no | 22 | - |
dc.relation.volume | 427 | - |
dc.identifier.doi | 10.1016/j.jmb.2015.07.017 | - |
dc.relation.page | 3457-3468 | - |
dc.relation.journal | JOURNAL OF MOLECULAR BIOLOGY | - |
dc.contributor.googleauthor | Li, Weixun | - |
dc.contributor.googleauthor | Bell, Harold W. | - |
dc.contributor.googleauthor | Ahnn, Joohong | - |
dc.contributor.googleauthor | Lee, Sun-Kyung | - |
dc.relation.code | 2015003732 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF NATURAL SCIENCES[S] | - |
dc.sector.department | DEPARTMENT OF LIFE SCIENCE | - |
dc.identifier.pid | joohong | - |
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