Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이종민 | - |
dc.date.accessioned | 2017-01-09T06:31:29Z | - |
dc.date.available | 2017-01-09T06:31:29Z | - |
dc.date.issued | 2015-05 | - |
dc.identifier.citation | ALZHEIMERS & DEMENTIA, v. 11, NO 5, Page. 494-503 | en_US |
dc.identifier.issn | 1552-5260 | - |
dc.identifier.issn | 1552-5279 | - |
dc.identifier.uri | http://www.sciencedirect.com/science/article/pii/S1552526014024194 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/24987 | - |
dc.description.abstract | Background: We investigated the independent effects of Alzheimer's disease (AD) and cerebrovascular disease (CVD) pathologies on brain structural changes and cognition. Methods: Amyloid burden (Pittsburgh compound B [PiB] retention ratio), CVD markers (volume of white matter hyperintensities [WMH] and number of lacunae), and structural changes (cortical thickness and hippocampal shape) were measured in 251 cognitively impaired patients. Path analyses were utilized to assess the effects of these markers on cognition. Results: PiB retention ratio was associated with hippocampal atrophy, which was associated with memory impairment. WMH were associated with frontal thinning, which was associated with executive and memory dysfunctions. PiB retention ratio and lacunae were also associated with memory and executive dysfunction without the mediation of hippocampal or frontal atrophy. Conclusions: Our results suggest that the impacts of AD and CVD pathologies on cognition are mediated by specific brain regions. (C) 2015 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved. | en_US |
dc.description.sponsorship | The authors would like to thank Victoria Barney for English correction. The authors also want to give special thanks to Changsoo Kim for his statistical advice. This study was supported by Basic Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF-2013R1A1A2065365), the Korean Healthcare Technology R&D Project Ministry for Health & Welfare Affairs (HI10C2020 & HIC120713), the KOSEF NRL program grant (MEST; 2011-0028333), Samsung Medical Center (CRL-108011&CRS 110-14-1), and the Converging Research Center Program through the Ministry of Science, ICT and Future Planning, Korea (2013K000338). | en_US |
dc.language.iso | en | en_US |
dc.publisher | ELSEVIER SCIENCE INC | en_US |
dc.subject | Cognition | en_US |
dc.subject | Amyloid | en_US |
dc.subject | Pittsburgh compound B | en_US |
dc.subject | Atrophy | en_US |
dc.subject | Cortical thickness | en_US |
dc.subject | Hippocampus | en_US |
dc.subject | Path analysis | en_US |
dc.subject | Cerebrovascular disease | en_US |
dc.title | Amyloid burden, cerebrovascular disease, brain atrophy, and cognition in cognitively impaired patients | en_US |
dc.type | Article | en_US |
dc.relation.no | 5 | - |
dc.relation.volume | 11 | - |
dc.identifier.doi | 10.1016/j.jalz.2014.04.521 | - |
dc.relation.page | 494-503 | - |
dc.relation.journal | ALZHEIMERS & DEMENTIA | - |
dc.contributor.googleauthor | Ye, Byoung Seok | - |
dc.contributor.googleauthor | Seo, Sang Won | - |
dc.contributor.googleauthor | Kim, Geon Ha | - |
dc.contributor.googleauthor | Noh, Young | - |
dc.contributor.googleauthor | Cho, Hanna | - |
dc.contributor.googleauthor | Yoon, Cindy W. | - |
dc.contributor.googleauthor | Kim, Hee Jin | - |
dc.contributor.googleauthor | Chin, Juhee | - |
dc.contributor.googleauthor | Jeon, Seun | - |
dc.contributor.googleauthor | Lee, Jong Min | - |
dc.relation.code | 2015011617 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF ENGINEERING[S] | - |
dc.sector.department | DIVISION OF ELECTRICAL AND BIOMEDICAL ENGINEERING | - |
dc.identifier.pid | ljm | - |
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