Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이종민 | - |
dc.date.accessioned | 2017-01-09T05:10:39Z | - |
dc.date.available | 2017-01-09T05:10:39Z | - |
dc.date.issued | 2015-05 | - |
dc.identifier.citation | HUMAN BRAIN MAPPING, v. 36, NO 5, Page. 1716-1727 | en_US |
dc.identifier.issn | 1065-9471 | - |
dc.identifier.issn | 1097-0193 | - |
dc.identifier.uri | http://onlinelibrary.wiley.com/doi/10.1002/hbm.22732/abstract;jsessionid=523D53BA5CA76A4946AAD9EFF618F8E7.f03t02 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/24985 | - |
dc.description.abstract | Olfactory performance in Parkinson's disease (PD) is closely associated with subsequent cognitive decline. In the present study, we analyzed the olfaction-dependent functional connectivity with a hypothesis that olfactory performance would influence functional connectivity within key brain areas of PD. A total of 110 nondemented drug-naive patients with PD were subdivided into three groups of high score (PD-H, n=23), middle score (PD-M, n=64), and low score (PD-L, n=23) based on olfactory performance. We performed the resting-state functional connectivity with seed region of interest in the posterior cingulate cortex (PCC) and caudate. An analysis of functional connectivity revealed that PD-L patients exhibited a significant attenuation of cortical functional connectivity with the PCC in the bilateral primary sensory areas, right frontal areas, and right parietal areas compared to PD-H or PD-M patients. Meanwhile, PD-L patients exhibited a significant enhancement of striatocortical functional connectivity in the bilateral occipital areas and right frontal areas compared to PD-H or PD-M patients. In the voxel-wise correlation analysis, olfactory performance was positively associated with cortical functional connectivity with the PCC in similar areas of attenuated cortical connectivity in PD-L patients relative to PD-H patients. On the other hand, the cortical functional connectivity with the caudate was negatively correlated with olfactory performance in similar areas of increased connectivity in PD-L patients relative to PD-H patients. The present study demonstrated that resting state functional connectivity exhibits a distinctive pattern depending on olfactory performance, which might shed light on a meaningful relationship between olfactory impairment and cognitive dysfunction in PD. Hum Brain Mapp 36:1716-1727, 2015. | en_US |
dc.description.sponsorship | Contract grant sponsor: Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and future Planning; Contract grant number: NRF-2013R1A2A2A01067761; Contract grant sponsor: National Research Foundation of Korea (NRF) grant funded by the Korea government (MEST); Contract grant number: 2011-0028333 | en_US |
dc.language.iso | en | en_US |
dc.publisher | WILEY-BLACKWELL | en_US |
dc.subject | Parkinson's disease | en_US |
dc.subject | resting state functional connectivity | en_US |
dc.subject | olfaction | en_US |
dc.subject | cognition | en_US |
dc.title | Olfactory Performance and Resting State Functional Connectivity in Non-demented Drug Naive Patients with Parkinson's Disease | en_US |
dc.type | Article | en_US |
dc.relation.no | 5 | - |
dc.relation.volume | 36 | - |
dc.identifier.doi | 10.1002/hbm.22732 | - |
dc.relation.page | 1716-1727 | - |
dc.relation.journal | HUMAN BRAIN MAPPING | - |
dc.contributor.googleauthor | Sunwoo, Mun Kyung | - |
dc.contributor.googleauthor | Cha, Jungho | - |
dc.contributor.googleauthor | Ham, Jee Hyun | - |
dc.contributor.googleauthor | Song, Sook K. | - |
dc.contributor.googleauthor | Hong, Jin Yong | - |
dc.contributor.googleauthor | Lee, Jong-Min | - |
dc.contributor.googleauthor | Sohn, Young H. | - |
dc.contributor.googleauthor | Lee, Phil Hyu | - |
dc.relation.code | 2015001549 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF ENGINEERING[S] | - |
dc.sector.department | DIVISION OF ELECTRICAL AND BIOMEDICAL ENGINEERING | - |
dc.identifier.pid | ljm | - |
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